Iptacopan in Idiopathic Immune Complex–Mediated Membranoproliferative Glomerulonephritis: Protocol of the APPARENT Multicenter, Randomized Phase 3 Study

Iptacopan in Idiopathic Immune Complex–Mediated Membranoproliferative Glomerulonephritis: Protocol of the APPARENT Multicenter, Randomized Phase 3 Study

Introduction: Immune complex–mediated membranoproliferative glomerulonephritis (IC-MPGN) is an ultra-rare, fast-progressing kidney disease that may be idiopathic (primary) or secondary to chronic infection, autoimmune disorders, or monoclonal gammopathies. Dysregulation of the alternative complement...

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Bibliographic Details
Main Authors: Marina Vivarelli, Andrew S. Bomback, Matthias Meier, Yaqin Wang, Nicholas J.A. Webb, Uday Kiran Veldandi, Richard J.H. Smith, David Kavanagh
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Kidney International Reports
Subjects:
alternative complement pathway
glomerular filtration rate
IC-MPGN
idiopathic immune complex–mediated membranoproliferative glomerulonephritis
iptacopan
phase 3 study design
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024923015620
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