Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA

Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA

Full-length hepatitis B virus (HBV) transcripts of chimpanzees and patients treated with multidose (MD) HBV siRNA ARC-520 and entecavir (ETV) were characterized by single-molecule real-time (SMRT) sequencing, identifying multiple types of transcripts with the potential to encode HBx, HBsAg, HBeAg, c...

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Bibliographic Details
Main Authors: Christine I. Wooddell, Dean Sanders, Zhao Xu, Lung-Yi Mak, Thomas Schluep, Wai-Kay Seto, Bruce D. Given, Man-Fung Yuen
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
hepatitis B virus transcription
hepatitis B virus RNA
HBV X
cccDNA
chronic hepatitis B
HBV siRNA
Online Access:https://www.mdpi.com/1999-4915/16/12/1943
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