DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS
Drug-induced gingival overgrowths (DIGO) represent a significant side effect of various pharmacological treatments, particularly anticonvulsants, immunosuppressants, and calcium channel blockers. This condition, characterized by the excessive growth of gum tissue, can lead to discomfort, aesthetic c...
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| Format: | Article |
| Language: | English |
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Romanian Dental Association for Education
2024-06-01
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| Series: | Romanian Journal of Medical and Dental Education |
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| Online Access: | https://journal.adre.ro/drug-induced-gingival-overgrowths-an-insight-into-molecular-mechanisms/ |
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| author | Gabriel Rotundu Diana Tatarciuc Bogdan Amărioarei Dana Budală Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian |
| author_facet | Gabriel Rotundu Diana Tatarciuc Bogdan Amărioarei Dana Budală Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian |
| author_sort | Gabriel Rotundu |
| collection | DOAJ |
| description | Drug-induced gingival overgrowths (DIGO) represent a significant side effect of various pharmacological treatments, particularly anticonvulsants, immunosuppressants, and calcium channel blockers. This condition, characterized by the excessive growth of gum tissue, can lead to discomfort, aesthetic concerns, and periodontal complications. Understanding the molecular mechanisms underlying DIGO is crucial for developing effective preventive and therapeutic strategies. This review aims to provide an in-depth analysis of the cellular and molecular pathways implicated in DIGO, including the roles of fibroblasts, inflammatory mediators, and genetic predispositions. By elucidating the interactions between these factors, we seek to highlight potential targets for intervention. Additionally, the review discusses current research advancements and potential future directions in the study of DIGO. Through this comprehensive examination, we aim to enhance the understanding of the implications of these mechanisms. |
| format | Article |
| id | doaj-art-f4d76e8c71ae4c32a5a24453dc1ee22b |
| institution | Kabale University |
| issn | 2393-1531 2393-1108 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Romanian Dental Association for Education |
| record_format | Article |
| series | Romanian Journal of Medical and Dental Education |
| spelling | doaj-art-f4d76e8c71ae4c32a5a24453dc1ee22b2025-01-08T08:07:16ZengRomanian Dental Association for EducationRomanian Journal of Medical and Dental Education2393-15312393-11082024-06-011336572DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMSGabriel Rotundu0Diana Tatarciuc1Bogdan Amărioarei2Dana Budală3Ruxandra Stan4Oana Butnaru5Alexandra Mârțu6Liliana Păsărin7Ionut Luchian8Department of Prosthodontics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Internal Medicine, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Prosthodontics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-Romania Department of Biophysics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași-RomaniaDrug-induced gingival overgrowths (DIGO) represent a significant side effect of various pharmacological treatments, particularly anticonvulsants, immunosuppressants, and calcium channel blockers. This condition, characterized by the excessive growth of gum tissue, can lead to discomfort, aesthetic concerns, and periodontal complications. Understanding the molecular mechanisms underlying DIGO is crucial for developing effective preventive and therapeutic strategies. This review aims to provide an in-depth analysis of the cellular and molecular pathways implicated in DIGO, including the roles of fibroblasts, inflammatory mediators, and genetic predispositions. By elucidating the interactions between these factors, we seek to highlight potential targets for intervention. Additionally, the review discusses current research advancements and potential future directions in the study of DIGO. Through this comprehensive examination, we aim to enhance the understanding of the implications of these mechanisms.https://journal.adre.ro/drug-induced-gingival-overgrowths-an-insight-into-molecular-mechanisms/drug-induced gingival overgrowthsmolecular mechanismimmunosuppressantscellular pathwaysgingival hyperplasia |
| spellingShingle | Gabriel Rotundu Diana Tatarciuc Bogdan Amărioarei Dana Budală Ruxandra Stan Oana Butnaru Alexandra Mârțu Liliana Păsărin Ionut Luchian DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS Romanian Journal of Medical and Dental Education drug-induced gingival overgrowths molecular mechanism immunosuppressants cellular pathways gingival hyperplasia |
| title | DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS |
| title_full | DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS |
| title_fullStr | DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS |
| title_full_unstemmed | DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS |
| title_short | DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS |
| title_sort | drug induced gingival overgrowths an insight into molecular mechanisms |
| topic | drug-induced gingival overgrowths molecular mechanism immunosuppressants cellular pathways gingival hyperplasia |
| url | https://journal.adre.ro/drug-induced-gingival-overgrowths-an-insight-into-molecular-mechanisms/ |
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