Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration
Purpose: Spectral-domain OCT angiography (SD-OCTA) scans were used in an algorithm developed for swept-source OCT angiography (SS-OCTA) scans to determine if SD-OCTA scans yielded similar results for the measurement of hyperreflective foci (HRF) in intermediate age-related macular degeneration (iAMD...
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Elsevier
2025-03-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914524001696 |
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| author | Gissel Herrera, MD Yuxuan Cheng, PhD Yamini Attiku, MD Farhan E. Hiya, MD Mengxi Shen, MD, PhD Jeremy Liu, MD Jie Lu, PhD Alessandro Berni, MD Omer Trivizki, MD Jianqing Li, MD Robert C. O’Brien, PhD Giovanni Gregori, PhD Ruikang K. Wang, PhD Philip J. Rosenfeld, MD, PhD |
| author_facet | Gissel Herrera, MD Yuxuan Cheng, PhD Yamini Attiku, MD Farhan E. Hiya, MD Mengxi Shen, MD, PhD Jeremy Liu, MD Jie Lu, PhD Alessandro Berni, MD Omer Trivizki, MD Jianqing Li, MD Robert C. O’Brien, PhD Giovanni Gregori, PhD Ruikang K. Wang, PhD Philip J. Rosenfeld, MD, PhD |
| author_sort | Gissel Herrera, MD |
| collection | DOAJ |
| description | Purpose: Spectral-domain OCT angiography (SD-OCTA) scans were used in an algorithm developed for swept-source OCT angiography (SS-OCTA) scans to determine if SD-OCTA scans yielded similar results for the measurement of hyperreflective foci (HRF) in intermediate age-related macular degeneration (iAMD). Design: Retrospective study. Participants: Forty eyes from 35 patients with iAMD. Methods: Patients underwent SD-OCTA and SS-OCTA imaging at the same visit using a 6 × 6 mm OCTA scan pattern. Hyperreflective foci were detected as hypotransmission defects on en face structural images generated from a custom slab positioned 64 to 400 μm beneath Bruch’s membrane and confirmed on corresponding B-scans by the presence of well circumscribed lesions within the neurosensory retina or along the retinal pigment epithelium (RPE) that are of equal or greater reflectivity than that of the RPE. Two independent graders evaluated the en face images and B-scans for the presence of these lesions. Outlines of HRF on en face images were generated using a published semiautomated algorithm developed for SS-OCTA scans and manually corrected by the graders when necessary. The total area measurements of the HRF within the 5-mm circle centered on the fovea were obtained from the algorithm using each imaging method. Main Outcome Measures: Agreement of the square root (sqrt) of the HRF total areas obtained from SS-OCTA and SD-OCTA. Results: The sqrt total areas of the HRF from both imaging modalities were highly concordant, with Lin’s concordance correlation coefficient (rc) of 0.94 (95% confidence interval: 0.86–0.97; P < 0.001). The mean sqrt of the total HRF area measurements identified using SS-OCTA and SD-OCTA imaging were 0.390 mm (standard deviation [SD]: 0.170) and 0.393 mm (SD: 0.187), respectively with mean difference of −0.003 (95% confidence interval: −0.021 to 0.015; P=0.76). Conclusions: Spectral-domain OCT angiography scans yielded results similar to SS-OCTA scans when the same semiautomated algorithm was used to measure HRF in the central 5 mm of the macula, suggesting that either a single 6 × 6 mm SD-OCTA or a SS-OCTA scan pattern can be used to determine the total macular HRF burden in eyes with age-related macular degeneration. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| format | Article |
| id | doaj-art-f4c6d7f28db74ad5a148bd9961647eb0 |
| institution | Kabale University |
| issn | 2666-9145 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Ophthalmology Science |
| spelling | doaj-art-f4c6d7f28db74ad5a148bd9961647eb02024-12-15T06:17:31ZengElsevierOphthalmology Science2666-91452025-03-0152100633Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular DegenerationGissel Herrera, MD0Yuxuan Cheng, PhD1Yamini Attiku, MD2Farhan E. Hiya, MD3Mengxi Shen, MD, PhD4Jeremy Liu, MD5Jie Lu, PhD6Alessandro Berni, MD7Omer Trivizki, MD8Jianqing Li, MD9Robert C. O’Brien, PhD10Giovanni Gregori, PhD11Ruikang K. Wang, PhD12Philip J. Rosenfeld, MD, PhD13Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Bioengineering, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, ConnecticutDepartment of Bioengineering, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, ItalyDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv, IsraelDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Department of Ophthalmology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FloridaDepartment of Bioengineering, University of Washington, Seattle, Washington; Department of Ophthalmology, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Correspondence: Philip J. Rosenfeld, MD, PhD, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136.Purpose: Spectral-domain OCT angiography (SD-OCTA) scans were used in an algorithm developed for swept-source OCT angiography (SS-OCTA) scans to determine if SD-OCTA scans yielded similar results for the measurement of hyperreflective foci (HRF) in intermediate age-related macular degeneration (iAMD). Design: Retrospective study. Participants: Forty eyes from 35 patients with iAMD. Methods: Patients underwent SD-OCTA and SS-OCTA imaging at the same visit using a 6 × 6 mm OCTA scan pattern. Hyperreflective foci were detected as hypotransmission defects on en face structural images generated from a custom slab positioned 64 to 400 μm beneath Bruch’s membrane and confirmed on corresponding B-scans by the presence of well circumscribed lesions within the neurosensory retina or along the retinal pigment epithelium (RPE) that are of equal or greater reflectivity than that of the RPE. Two independent graders evaluated the en face images and B-scans for the presence of these lesions. Outlines of HRF on en face images were generated using a published semiautomated algorithm developed for SS-OCTA scans and manually corrected by the graders when necessary. The total area measurements of the HRF within the 5-mm circle centered on the fovea were obtained from the algorithm using each imaging method. Main Outcome Measures: Agreement of the square root (sqrt) of the HRF total areas obtained from SS-OCTA and SD-OCTA. Results: The sqrt total areas of the HRF from both imaging modalities were highly concordant, with Lin’s concordance correlation coefficient (rc) of 0.94 (95% confidence interval: 0.86–0.97; P < 0.001). The mean sqrt of the total HRF area measurements identified using SS-OCTA and SD-OCTA imaging were 0.390 mm (standard deviation [SD]: 0.170) and 0.393 mm (SD: 0.187), respectively with mean difference of −0.003 (95% confidence interval: −0.021 to 0.015; P=0.76). Conclusions: Spectral-domain OCT angiography scans yielded results similar to SS-OCTA scans when the same semiautomated algorithm was used to measure HRF in the central 5 mm of the macula, suggesting that either a single 6 × 6 mm SD-OCTA or a SS-OCTA scan pattern can be used to determine the total macular HRF burden in eyes with age-related macular degeneration. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.http://www.sciencedirect.com/science/article/pii/S2666914524001696Age-related macular degeneration (AMD)Hyperreflective foci (HRF)Hypotransmission defect (HypoTD)Spectral-domain OCT angiography (SD-OCTA)Swept-source OCT angiography (SS-OCTA) |
| spellingShingle | Gissel Herrera, MD Yuxuan Cheng, PhD Yamini Attiku, MD Farhan E. Hiya, MD Mengxi Shen, MD, PhD Jeremy Liu, MD Jie Lu, PhD Alessandro Berni, MD Omer Trivizki, MD Jianqing Li, MD Robert C. O’Brien, PhD Giovanni Gregori, PhD Ruikang K. Wang, PhD Philip J. Rosenfeld, MD, PhD Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration Ophthalmology Science Age-related macular degeneration (AMD) Hyperreflective foci (HRF) Hypotransmission defect (HypoTD) Spectral-domain OCT angiography (SD-OCTA) Swept-source OCT angiography (SS-OCTA) |
| title | Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration |
| title_full | Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration |
| title_fullStr | Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration |
| title_full_unstemmed | Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration |
| title_short | Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration |
| title_sort | comparison between spectral domain and swept source oct angiography scans for the measurement of hyperreflective foci in age related macular degeneration |
| topic | Age-related macular degeneration (AMD) Hyperreflective foci (HRF) Hypotransmission defect (HypoTD) Spectral-domain OCT angiography (SD-OCTA) Swept-source OCT angiography (SS-OCTA) |
| url | http://www.sciencedirect.com/science/article/pii/S2666914524001696 |
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