Inhibition of histone methyltransferase G9a promotes the osteogenic potential of bone-derived stem cells in diabetic-osteoporosis by regulating the LINC00657/miR-204-5p/IGFBP5 pathway

Inhibition of histone methyltransferase G9a promotes the osteogenic potential of bone-derived stem cells in diabetic-osteoporosis by regulating the LINC00657/miR-204-5p/IGFBP5 pathway

BackgroundBone mesenchymal stem cells (BMSCs) from patients with diabetes often exhibit reduced osteogenic potential. This study aimed to investigate the mechanism of action of G9a, known as euchromatic histone lysine methyltransferase 2 (EHMT2), identify its key responsive long non-coding RNA in di...

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Bibliographic Details
Main Authors: Mei-qi Qiao, Bin Wang, Jian-pin Fan, Feng Gao, Shao-jun Wang, Sheng-yang Guo, Sheng-li Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
G9a inhibitor
diabetic osteoporosis
LINC00657
miR-204-5p
IGFBP5
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1625944/full
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