Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trialResearch in context

Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trialResearch in context

Summary: Background: Rhabdomyosarcoma and other soft tissue sarcomas (STS) with high-risk features are still associated with an unsatisfactory outcome. We evaluated the efficacy of oral maintenance therapy added at the end of standard therapy in patients with high-risk rhabdomyosarcoma and STS. Met...

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Main Authors: Ewa Koscielniak, Gustaf Ljungman, Bernarda Kazanowska, Felix Niggli, Monika Sparber-Sauer, Rupert Handgretinger, Martin Zimmermann, Joachim Boos, Bernd Blank, Erika Hallmen, Irene Teichert von Lüttichau, Irene Schmid, Birgit Fröhlich, Hermann L. Müller, Wolfgang Behnisch, Ruth Ladenstein, Monika Scheer, Christian Vokuhl, Thekla von Kalle, Claudia Blattmann, Stefan Bielack, Thomas Klingebiel
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EClinicalMedicine
Subjects:
Rhabdomyosarcoma
Soft tissue sarcoma
Maintenance therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537024005364
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