Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two major fermentable fuels: glucose and...

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Main Authors: Tomás Duraj, Miriam Kalamian, Giulio Zuccoli, Joseph C. Maroon, Dominic P. D’Agostino, Adrienne C. Scheck, Angela Poff, Sebastian F. Winter, Jethro Hu, Rainer J. Klement, Alicia Hickson, Derek C. Lee, Isabella Cooper, Barbara Kofler, Kenneth A. Schwartz, Matthew C. L. Phillips, Colin E. Champ, Beth Zupec-Kania, Jocelyn Tan-Shalaby, Fabiano M. Serfaty, Egiroh Omene, Gabriel Arismendi-Morillo, Michael Kiebish, Richard Cheng, Ahmed M. El-Sakka, Axel Pflueger, Edward H. Mathews, Donese Worden, Hanping Shi, Raffaele Ivan Cincione, Jean Pierre Spinosa, Abdul Kadir Slocum, Mehmet Salih Iyikesici, Atsuo Yanagisawa, Geoffrey J. Pilkington, Anthony Chaffee, Wafaa Abdel-Hadi, Amr K. Elsamman, Pavel Klein, Keisuke Hagihara, Zsófia Clemens, George W. Yu, Athanasios E. Evangeliou, Janak K. Nathan, Kris Smith, David Fortin, Jorg Dietrich, Purna Mukherjee, Thomas N. Seyfried
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Medicine
Subjects:
Cancer
Glioblastoma
Metabolism
Research design
Warburg Effect
Glutaminolysis
Online Access:https://doi.org/10.1186/s12916-024-03775-4
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