Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures
Introduction: Neuroendoscopy has become a well-established procedure for treating various intracranial conditions. Research question: We evaluated the advantages of that technique, with focus on adverse events. Material and methods: Retrospective analysis included all patients who underwent neuroend...
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Elsevier
2024-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529424013985 |
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| author | Mohammed Issa Clara Dannehl Carmen J. Büsken Nieke Ueding Angelika Seitz Sandro M. Krieg Andreas W. Unterberg Ahmed El Damaty |
| author_facet | Mohammed Issa Clara Dannehl Carmen J. Büsken Nieke Ueding Angelika Seitz Sandro M. Krieg Andreas W. Unterberg Ahmed El Damaty |
| author_sort | Mohammed Issa |
| collection | DOAJ |
| description | Introduction: Neuroendoscopy has become a well-established procedure for treating various intracranial conditions. Research question: We evaluated the advantages of that technique, with focus on adverse events. Material and methods: Retrospective analysis included all patients who underwent neuroendoscopic procedures between January 2017 and December 2023. We conducted comparative analysis considering factors such as age, gender, follow-up duration, etiology, preoperative symptoms, clinical and radiological benefits, as well as surgical and nonsurgical adverse events rates. Results: Total of 318 neuroendoscopic procedures within 257 surgeries in 225 patients were included, with mean age of 18.8 ± 21.4 years. 170 cases (66.1%) were pediatric versus 87 cases adults (33.9%). Most common aetiologies were peri- and intraventricular cysts (27.2%), idiopathic aqueduct stenosis (24.9%), tumours (23.7%), and post-haemorrhagic hydrocephalus (17.1%). Procedures included endoscopic third ventriculostomy (51.0%), cyst fenestration (21.0%), and endoscopic-assisted ventricular catheter placements (19.5%). Headache was predominant preoperative symptom (42.0%). During follow-up, 84.8% and 82.5% of cases showed clinical and radiological improvement, respectively. Early surgical adverse events were observed in 5.4% of cases, while non-surgical adverse events occurred in 3.1%. There was no significant difference in the surgical adverse events rate between children and adults (4.7% vs. 6.9%, p = 0.563), compared to significant higher non-surgical adverse events in adults (6.9% vs 1.2%, p=0.020). Discussion and conclusion: Neuroendoscopy has demonstrated effectiveness and safety in treating intracranial diseases, boasting a low adverse events rate. Our study found no significant difference in the surgical adverse events rates between pediatric and adult groups. |
| format | Article |
| id | doaj-art-f48b69d20e524b1f9ffe47f5433f3725 |
| institution | Kabale University |
| issn | 2772-5294 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj-art-f48b69d20e524b1f9ffe47f5433f37252024-12-15T06:18:54ZengElsevierBrain and Spine2772-52942024-01-014104142Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic proceduresMohammed Issa0Clara Dannehl1Carmen J. Büsken2Nieke Ueding3Angelika Seitz4Sandro M. Krieg5Andreas W. Unterberg6Ahmed El Damaty7Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, Germany; Corresponding author. Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany; Faculty of Medicine, Heidelberg University, Heidelberg, GermanyIntroduction: Neuroendoscopy has become a well-established procedure for treating various intracranial conditions. Research question: We evaluated the advantages of that technique, with focus on adverse events. Material and methods: Retrospective analysis included all patients who underwent neuroendoscopic procedures between January 2017 and December 2023. We conducted comparative analysis considering factors such as age, gender, follow-up duration, etiology, preoperative symptoms, clinical and radiological benefits, as well as surgical and nonsurgical adverse events rates. Results: Total of 318 neuroendoscopic procedures within 257 surgeries in 225 patients were included, with mean age of 18.8 ± 21.4 years. 170 cases (66.1%) were pediatric versus 87 cases adults (33.9%). Most common aetiologies were peri- and intraventricular cysts (27.2%), idiopathic aqueduct stenosis (24.9%), tumours (23.7%), and post-haemorrhagic hydrocephalus (17.1%). Procedures included endoscopic third ventriculostomy (51.0%), cyst fenestration (21.0%), and endoscopic-assisted ventricular catheter placements (19.5%). Headache was predominant preoperative symptom (42.0%). During follow-up, 84.8% and 82.5% of cases showed clinical and radiological improvement, respectively. Early surgical adverse events were observed in 5.4% of cases, while non-surgical adverse events occurred in 3.1%. There was no significant difference in the surgical adverse events rate between children and adults (4.7% vs. 6.9%, p = 0.563), compared to significant higher non-surgical adverse events in adults (6.9% vs 1.2%, p=0.020). Discussion and conclusion: Neuroendoscopy has demonstrated effectiveness and safety in treating intracranial diseases, boasting a low adverse events rate. Our study found no significant difference in the surgical adverse events rates between pediatric and adult groups.http://www.sciencedirect.com/science/article/pii/S2772529424013985NeuroendoscopyIntracranialAdverse events and endoscopic third ventriculostomy |
| spellingShingle | Mohammed Issa Clara Dannehl Carmen J. Büsken Nieke Ueding Angelika Seitz Sandro M. Krieg Andreas W. Unterberg Ahmed El Damaty Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures Brain and Spine Neuroendoscopy Intracranial Adverse events and endoscopic third ventriculostomy |
| title | Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures |
| title_full | Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures |
| title_fullStr | Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures |
| title_full_unstemmed | Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures |
| title_short | Assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies: A single-centre retrospective study with 318 intracranial endoscopic procedures |
| title_sort | assessment of the efficacy and safety of neuroendoscopic procedures for intracranial pathologies a single centre retrospective study with 318 intracranial endoscopic procedures |
| topic | Neuroendoscopy Intracranial Adverse events and endoscopic third ventriculostomy |
| url | http://www.sciencedirect.com/science/article/pii/S2772529424013985 |
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