Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis

Abstract Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an assoc...

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Main Authors: Yang Luo, Chuan-Chin Huang, Nicole C. Howard, Xin Wang, Qingyun Liu, Xinyi Li, Junhao Zhu, Tiffany Amariuta, Samira Asgari, Kazuyoshi Ishigaki, Roger Calderon, Sahadevan Raman, Alexandrea K. Ramnarine, Jacob A. Mayfield, D. Branch Moody, Leonid Lecca, Sarah M. Fortune, Megan B. Murray, Soumya Raychaudhuri
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54741-w
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https://doi.org/10.1038/s41467-024-54741-w

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