One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer

Abstract Intratumoral heterogeneity (ITH), arising from various factors, plays a crucial role in diverse cancers, yet research on ITH remains in its early stages. To explore this phenomenon further, we conducted single-nuclei transcriptome profiling on patient-derived organoids (PDOs) from two histo...

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Bibliographic Details
Main Authors: Seyeon Joo, Yoojin Bae, Bo Kyung Yoon, Yeonjin Je, Yuna Kim, Minki Kim, Su-Jin Shin, Sungsoon Fang, Jie-Hyun Kim
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02704-5
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