Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct
<b>Background and Purpose</b>: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI...
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MDPI AG
2024-11-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/11/11/345 |
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| author | Caterina Sozzi Carla Brenlla Inés Bartolomé Andrés Girona Emma Muñoz-Moreno Carlos Laredo Alejandro Rodríguez-Vázquez Antonio Doncel-Moriano Salvatore Rudilosso Ángel Chamorro |
| author_facet | Caterina Sozzi Carla Brenlla Inés Bartolomé Andrés Girona Emma Muñoz-Moreno Carlos Laredo Alejandro Rodríguez-Vázquez Antonio Doncel-Moriano Salvatore Rudilosso Ángel Chamorro |
| author_sort | Caterina Sozzi |
| collection | DOAJ |
| description | <b>Background and Purpose</b>: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correlation with clinical and imaging factors. <b>Materials and Methods</b>: In a cohort of 71 patients with an RSSI with complete clinical data, including the Pittsburgh Sleep Quality Index (PSQI), we segmented PVS in white matter (WM-PVS), basal ganglia (BG-PVS), and brainstems (BS-PVS) on 3T-MRI T2-weighted sequences, obtaining fractional volumes (%), and calculated the WM/BG-PVS ratio. We analyzed the Pearson’s correlation coefficients between PVS regional loads. We used normalized PVS measures to assess the associations with clinical and MRI-SVD features (white matter hyperintensities (WMHs), number of lacunes, and microbleeds) in univariable and multivariable linear regressions adjusted for age, sex, and hypertension. <b>Results</b>: In our cohort (mean age 70 years; 27% female), the Pearson’s correlation coefficients between WM-PVS/BG-PVS, WM-PVS/BS-PVS, and BG-PVS/BS-PVS were 0.67, 0.61, and 0.59 (all <i>p</i> < 0.001). In the adjusted models, BG-PVS were associated with lacunes (<i>p</i> = 0.034), WMHs (<i>p</i> = 0.006), and microbleeds (<i>p</i> = 0.017); WM-PVS with lacunes (<i>p</i> = 0.003); while BS-PVS showed no associations. The WM/BG-PVS ratio was associated with lacunes (<i>p</i> = 0.018) and the PSQI (<i>p</i> = 0.046). <b>Conclusions</b>: PVS burdens in different regions are highly correlated in patients with RSSI but with different SVD patterns. Sleep quality impairment might affect waste removal mechanisms differently in the WM and BG regions. |
| format | Article |
| id | doaj-art-f46f8b8c8a1e40d3b98dcb63a7c1d4eb |
| institution | OA Journals |
| issn | 2308-3425 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj-art-f46f8b8c8a1e40d3b98dcb63a7c1d4eb2025-08-20T01:53:53ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252024-11-01111134510.3390/jcdd11110345Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical InfarctCaterina Sozzi0Carla Brenlla1Inés Bartolomé2Andrés Girona3Emma Muñoz-Moreno4Carlos Laredo5Alejandro Rodríguez-Vázquez6Antonio Doncel-Moriano7Salvatore Rudilosso8Ángel Chamorro9Neurology Department, University of Milano Bicocca, 20126 Milan, ItalyNeurology Department, Hospital Clínic, 08036 Barcelona, SpainNeurology Department, Hospital Clínic, 08036 Barcelona, SpainNeurology Department, Hospital Clínic, 08036 Barcelona, SpainAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, SpainAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, SpainComprehensive Stroke Center, Department of Neuroscience, Hospital Clínic, 08036 Barcelona, SpainComprehensive Stroke Center, Department of Neuroscience, Hospital Clínic, 08036 Barcelona, SpainAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, SpainAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain<b>Background and Purpose</b>: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correlation with clinical and imaging factors. <b>Materials and Methods</b>: In a cohort of 71 patients with an RSSI with complete clinical data, including the Pittsburgh Sleep Quality Index (PSQI), we segmented PVS in white matter (WM-PVS), basal ganglia (BG-PVS), and brainstems (BS-PVS) on 3T-MRI T2-weighted sequences, obtaining fractional volumes (%), and calculated the WM/BG-PVS ratio. We analyzed the Pearson’s correlation coefficients between PVS regional loads. We used normalized PVS measures to assess the associations with clinical and MRI-SVD features (white matter hyperintensities (WMHs), number of lacunes, and microbleeds) in univariable and multivariable linear regressions adjusted for age, sex, and hypertension. <b>Results</b>: In our cohort (mean age 70 years; 27% female), the Pearson’s correlation coefficients between WM-PVS/BG-PVS, WM-PVS/BS-PVS, and BG-PVS/BS-PVS were 0.67, 0.61, and 0.59 (all <i>p</i> < 0.001). In the adjusted models, BG-PVS were associated with lacunes (<i>p</i> = 0.034), WMHs (<i>p</i> = 0.006), and microbleeds (<i>p</i> = 0.017); WM-PVS with lacunes (<i>p</i> = 0.003); while BS-PVS showed no associations. The WM/BG-PVS ratio was associated with lacunes (<i>p</i> = 0.018) and the PSQI (<i>p</i> = 0.046). <b>Conclusions</b>: PVS burdens in different regions are highly correlated in patients with RSSI but with different SVD patterns. Sleep quality impairment might affect waste removal mechanisms differently in the WM and BG regions.https://www.mdpi.com/2308-3425/11/11/345cerebral small vessel diseaselacunar strokeperivascular spacessleep |
| spellingShingle | Caterina Sozzi Carla Brenlla Inés Bartolomé Andrés Girona Emma Muñoz-Moreno Carlos Laredo Alejandro Rodríguez-Vázquez Antonio Doncel-Moriano Salvatore Rudilosso Ángel Chamorro Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct Journal of Cardiovascular Development and Disease cerebral small vessel disease lacunar stroke perivascular spaces sleep |
| title | Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct |
| title_full | Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct |
| title_fullStr | Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct |
| title_full_unstemmed | Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct |
| title_short | Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct |
| title_sort | clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct |
| topic | cerebral small vessel disease lacunar stroke perivascular spaces sleep |
| url | https://www.mdpi.com/2308-3425/11/11/345 |
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