Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies
Background: Craniosynostosis (CS) is a congenital birth defect characterized by the premature fusion of one or several calvarial suture(s). CS could lead to serious complications, such as intracranial hypertension and neurodevelopmental impairment. There is an increasing trend in the prevalence of C...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426820301846 |
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| author | Kenzy Abdelhamid Rea Konci Hassan ElHawary Andrew Gorgy Lee Smith |
| author_facet | Kenzy Abdelhamid Rea Konci Hassan ElHawary Andrew Gorgy Lee Smith |
| author_sort | Kenzy Abdelhamid |
| collection | DOAJ |
| description | Background: Craniosynostosis (CS) is a congenital birth defect characterized by the premature fusion of one or several calvarial suture(s). CS could lead to serious complications, such as intracranial hypertension and neurodevelopmental impairment. There is an increasing trend in the prevalence of CS – 75% of which are of non-syndromic type (NSCS). In parallel, there is a steady rise in the average maternal age. The goal of this paper was to review the literature to clearly identify any associations between parental age and NSCS. This review was performed and reported in compliance with PRISMA guidelines. Methods: The PUBMED and EMBASE databases were systematically searched, and all studies that observed the relationship between maternal and/or paternal age on NSCS were included. The articles were then assessed for methodological quality using the Newcastle–Ottawa Scale (NOS). The effect of advanced maternal and/or paternal age on the incidence of NSCS was identified by the prevalence ratios reported at a confidence interval of 95%. Results: Six retrospective case-control studies, reporting on a total of 3267 cases of NSCS were included in this review. While there were some inconsistencies in the findings of the different studies, the majority reported a positive correlation between advanced maternal and/or paternal age and an increased incidence of NSCS. Conclusion: This review identified an association between advanced parental age and an increased incidence of NSCS. |
| format | Article |
| id | doaj-art-f464b32ec5b34bdea4ef9694a688ced0 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-f464b32ec5b34bdea4ef9694a688ced02024-11-23T06:28:32ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682021-01-011117883Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studiesKenzy Abdelhamid0Rea Konci1Hassan ElHawary2Andrew Gorgy3Lee Smith4Faculty of Medicine, McGill University, Montreal, Quebec, CanadaDepartment of Obstetrics and Gynecology, McGill University, Montreal, Quebec, CanadaDivision of Plastic and Reconstructive Surgery, McGill University, Montreal, Quebec, Canada; Corresponding author. Division of Plastic and Reconstructive Surgery, McGill University Health Center, Canada.Department of Surgery, McGill University, Montreal, Quebec, CanadaThe Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UKBackground: Craniosynostosis (CS) is a congenital birth defect characterized by the premature fusion of one or several calvarial suture(s). CS could lead to serious complications, such as intracranial hypertension and neurodevelopmental impairment. There is an increasing trend in the prevalence of CS – 75% of which are of non-syndromic type (NSCS). In parallel, there is a steady rise in the average maternal age. The goal of this paper was to review the literature to clearly identify any associations between parental age and NSCS. This review was performed and reported in compliance with PRISMA guidelines. Methods: The PUBMED and EMBASE databases were systematically searched, and all studies that observed the relationship between maternal and/or paternal age on NSCS were included. The articles were then assessed for methodological quality using the Newcastle–Ottawa Scale (NOS). The effect of advanced maternal and/or paternal age on the incidence of NSCS was identified by the prevalence ratios reported at a confidence interval of 95%. Results: Six retrospective case-control studies, reporting on a total of 3267 cases of NSCS were included in this review. While there were some inconsistencies in the findings of the different studies, the majority reported a positive correlation between advanced maternal and/or paternal age and an increased incidence of NSCS. Conclusion: This review identified an association between advanced parental age and an increased incidence of NSCS.http://www.sciencedirect.com/science/article/pii/S2212426820301846CraniosynostosesAdvanced parental ageAdvanced maternal ageAdvanced paternal age |
| spellingShingle | Kenzy Abdelhamid Rea Konci Hassan ElHawary Andrew Gorgy Lee Smith Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies Journal of Oral Biology and Craniofacial Research Craniosynostoses Advanced parental age Advanced maternal age Advanced paternal age |
| title | Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies |
| title_full | Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies |
| title_fullStr | Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies |
| title_full_unstemmed | Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies |
| title_short | Advanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies |
| title_sort | advanced parental age is it contributing to an increased incidence of non syndromic craniosynostosis a review of case control studies |
| topic | Craniosynostoses Advanced parental age Advanced maternal age Advanced paternal age |
| url | http://www.sciencedirect.com/science/article/pii/S2212426820301846 |
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