Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs
Pdgfrα+ stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224000618 |
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| author | Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao |
| author_facet | Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao |
| author_sort | Xia Kang |
| collection | DOAJ |
| description | Pdgfrα+ stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the similarities and differences between distinct tissue-resident Pdgfrα+ stromal cells is helpful for us to more comprehensively and deeply understand the behaviors of these cells and to explore some common regulating mechanisms and therapeutical targets. In this review, we summarize previous and current findings on Pdgfrα+ stromal cells in various tissues and discuss the crosstalk between Pdgfrα+ stromal cells and microenvironment. |
| format | Article |
| id | doaj-art-f44cda275c62436d889523eea9c3ef85 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-f44cda275c62436d889523eea9c3ef852024-12-26T08:56:23ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-03-01122101264Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organsXia Kang0Kun Zhao1Zhu Huang2So-ichiro Fukada3Xiao-wei Qi4Hongming Miao5Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China; Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan 610000, ChinaDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, ChinaPancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan 610000, ChinaProject for Muscle Stem Cell Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 564-0871, Japan; Corresponding author.Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China; Corresponding author.Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China; Jinfeng Laboratory, Chongqing 401329, China; Corresponding author. Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.Pdgfrα+ stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the similarities and differences between distinct tissue-resident Pdgfrα+ stromal cells is helpful for us to more comprehensively and deeply understand the behaviors of these cells and to explore some common regulating mechanisms and therapeutical targets. In this review, we summarize previous and current findings on Pdgfrα+ stromal cells in various tissues and discuss the crosstalk between Pdgfrα+ stromal cells and microenvironment.http://www.sciencedirect.com/science/article/pii/S2352304224000618Fatty infiltrationFibrosisPdgfrα+stromal cellTissue degenerationTissue regeneration |
| spellingShingle | Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs Genes and Diseases Fatty infiltration Fibrosis Pdgfrα+stromal cell Tissue degeneration Tissue regeneration |
| title | Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs |
| title_full | Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs |
| title_fullStr | Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs |
| title_full_unstemmed | Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs |
| title_short | Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs |
| title_sort | pdgfrα stromal cells a key regulator for tissue homeostasis and dysfunction in distinct organs |
| topic | Fatty infiltration Fibrosis Pdgfrα+stromal cell Tissue degeneration Tissue regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224000618 |
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