m6A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma

m6A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma

Abstract Alternative splicing (AS) generates protein diversity and is exploited by cancer cells to drive tumor progression and resistance to many cancer therapies, including chemotherapy. SNRPA is first identified as a spliceosome‐related gene that potentially modulates resistance to platinum chemot...

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Bibliographic Details
Main Authors: Weina Fan, Jian Huang, Fanglin Tian, Xin Hong, Kexin Zhu, Yuning Zhan, Xin Li, Xiangyu Wang, Xin Wang, Li Cai, Ying Xing
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
alternative splicing
cisplatin resistance
DNA repair
ELAVL1
ERCC1
SNRPA
Online Access:https://doi.org/10.1002/advs.202404609
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