Diabetes and gut microbiome
Diabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence is heterogeneous depending on region, country, economic situation, lifestyle, diet and level of medical care, it is increasing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1451054/full |
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| author | Kateřina Olša Fliegerová Tiziana Maria Mahayri Tiziana Maria Mahayri Hana Sechovcová Hana Sechovcová Chahrazed Mekadim Jakub Mrázek Radka Jarošíková Radka Jarošíková Michal Dubský Vladimíra Fejfarová Vladimíra Fejfarová |
| author_facet | Kateřina Olša Fliegerová Tiziana Maria Mahayri Tiziana Maria Mahayri Hana Sechovcová Hana Sechovcová Chahrazed Mekadim Jakub Mrázek Radka Jarošíková Radka Jarošíková Michal Dubský Vladimíra Fejfarová Vladimíra Fejfarová |
| author_sort | Kateřina Olša Fliegerová |
| collection | DOAJ |
| description | Diabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence is heterogeneous depending on region, country, economic situation, lifestyle, diet and level of medical care, it is increasing worldwide, especially among youths and children, mainly due to lifestyle and environmental changes. The pathogenesis of the two most common subtypes of diabetes mellitus, type 1 (T1DM) and type 2 (T2DM), is substantially different, so each form is characterized by a different causation, etiology, pathophysiology, presentation, and treatment. Research in recent decades increasingly indicates the potential role of the gut microbiome in the initiation, development, and progression of this disease. Intestinal microbes and their fermentation products have an important impact on host metabolism, immune system, nutrient digestion and absorption, gut barrier integrity and protection against pathogens. This review summarizes the current evidence on the changes in gut microbial populations in both types of diabetes mellitus. Attention is focused on changes in the abundance of specific bacterial groups at different taxonomic levels in humans, and microbiome shift is also assessed in relation to geographic location, age, diet and antidiabetic drug. The causal relationship between gut bacteria and diabetes is still unclear, and future studies applying new methodological approaches to a broader range of microorganisms inhabiting the digestive tract are urgently needed. This would not only provide a better understanding of the role of the gut microbiome in this metabolic disease, but also the use of beneficial bacterial species in the form of probiotics for the treatment of diabetes. |
| format | Article |
| id | doaj-art-f43e8d4a425b405dbded048212e1816b |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-f43e8d4a425b405dbded048212e1816b2025-01-07T06:41:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.14510541451054Diabetes and gut microbiomeKateřina Olša Fliegerová0Tiziana Maria Mahayri1Tiziana Maria Mahayri2Hana Sechovcová3Hana Sechovcová4Chahrazed Mekadim5Jakub Mrázek6Radka Jarošíková7Radka Jarošíková8Michal Dubský9Vladimíra Fejfarová10Vladimíra Fejfarová11Laboratory of Anaerobic Microbiology, Institute of Animal Physiology and Genetics, CAS, Prague, CzechiaLaboratory of Anaerobic Microbiology, Institute of Animal Physiology and Genetics, CAS, Prague, CzechiaDepartment of Veterinary Medicine, University of Sassari, Sassari, ItalyLaboratory of Anaerobic Microbiology, Institute of Animal Physiology and Genetics, CAS, Prague, CzechiaDepartment of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague, CzechiaLaboratory of Anaerobic Microbiology, Institute of Animal Physiology and Genetics, CAS, Prague, CzechiaLaboratory of Anaerobic Microbiology, Institute of Animal Physiology and Genetics, CAS, Prague, CzechiaInstitute for Clinical and Experimental Medicine, Diabetes Centre, Prague, CzechiaDepartment of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, CzechiaInstitute for Clinical and Experimental Medicine, Diabetes Centre, Prague, CzechiaInstitute for Clinical and Experimental Medicine, Diabetes Centre, Prague, CzechiaDepartment of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, CzechiaDiabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence is heterogeneous depending on region, country, economic situation, lifestyle, diet and level of medical care, it is increasing worldwide, especially among youths and children, mainly due to lifestyle and environmental changes. The pathogenesis of the two most common subtypes of diabetes mellitus, type 1 (T1DM) and type 2 (T2DM), is substantially different, so each form is characterized by a different causation, etiology, pathophysiology, presentation, and treatment. Research in recent decades increasingly indicates the potential role of the gut microbiome in the initiation, development, and progression of this disease. Intestinal microbes and their fermentation products have an important impact on host metabolism, immune system, nutrient digestion and absorption, gut barrier integrity and protection against pathogens. This review summarizes the current evidence on the changes in gut microbial populations in both types of diabetes mellitus. Attention is focused on changes in the abundance of specific bacterial groups at different taxonomic levels in humans, and microbiome shift is also assessed in relation to geographic location, age, diet and antidiabetic drug. The causal relationship between gut bacteria and diabetes is still unclear, and future studies applying new methodological approaches to a broader range of microorganisms inhabiting the digestive tract are urgently needed. This would not only provide a better understanding of the role of the gut microbiome in this metabolic disease, but also the use of beneficial bacterial species in the form of probiotics for the treatment of diabetes.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1451054/fullgut microbiotadiabetes mellitusT1DMT2DMantidiabetic drugs |
| spellingShingle | Kateřina Olša Fliegerová Tiziana Maria Mahayri Tiziana Maria Mahayri Hana Sechovcová Hana Sechovcová Chahrazed Mekadim Jakub Mrázek Radka Jarošíková Radka Jarošíková Michal Dubský Vladimíra Fejfarová Vladimíra Fejfarová Diabetes and gut microbiome Frontiers in Microbiology gut microbiota diabetes mellitus T1DM T2DM antidiabetic drugs |
| title | Diabetes and gut microbiome |
| title_full | Diabetes and gut microbiome |
| title_fullStr | Diabetes and gut microbiome |
| title_full_unstemmed | Diabetes and gut microbiome |
| title_short | Diabetes and gut microbiome |
| title_sort | diabetes and gut microbiome |
| topic | gut microbiota diabetes mellitus T1DM T2DM antidiabetic drugs |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1451054/full |
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