Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen
Stenotrophomonas maltophilia is a ubiquitous Gram-negative rod which has emerged as one of the major causes of nosocomial infections. It can cause pneumonia, septicemia, meningitis, urinary tract, and wound infections, and is associated with high mortality in immune-compromised patients. Pathogenesi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of the Scientific Society |
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| Online Access: | https://journals.lww.com/10.4103/jss.jss_59_24 |
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| author | Ruchita Gawande Suvarna Sande |
| author_facet | Ruchita Gawande Suvarna Sande |
| author_sort | Ruchita Gawande |
| collection | DOAJ |
| description | Stenotrophomonas maltophilia is a ubiquitous Gram-negative rod which has emerged as one of the major causes of nosocomial infections. It can cause pneumonia, septicemia, meningitis, urinary tract, and wound infections, and is associated with high mortality in immune-compromised patients. Pathogenesis in S. maltophilia infections is an outcome of multiple virulence factors, including outer membrane lipopolysaccharide, extracellular enzymes, porins, pilli, biofilm formation, motility, and small colony variants, among others. S. maltophilia shows high intrinsic and acquired resistance to all commonly used antibiotics, limiting the number of therapeutic choices. The aim of this review is to summarize the virulence factors, antibiotic resistance mechanisms, diagnosis, and treatment of S. maltophilia infections. |
| format | Article |
| id | doaj-art-f419d55372bc43be935804c4226de2c4 |
| institution | Kabale University |
| issn | 0974-5009 2278-7127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj-art-f419d55372bc43be935804c4226de2c42025-01-07T07:23:01ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092278-71272024-12-0151450551010.4103/jss.jss_59_24Stenotrophomonas maltophilia – A Threatening Nosocomial PathogenRuchita GawandeSuvarna SandeStenotrophomonas maltophilia is a ubiquitous Gram-negative rod which has emerged as one of the major causes of nosocomial infections. It can cause pneumonia, septicemia, meningitis, urinary tract, and wound infections, and is associated with high mortality in immune-compromised patients. Pathogenesis in S. maltophilia infections is an outcome of multiple virulence factors, including outer membrane lipopolysaccharide, extracellular enzymes, porins, pilli, biofilm formation, motility, and small colony variants, among others. S. maltophilia shows high intrinsic and acquired resistance to all commonly used antibiotics, limiting the number of therapeutic choices. The aim of this review is to summarize the virulence factors, antibiotic resistance mechanisms, diagnosis, and treatment of S. maltophilia infections.https://journals.lww.com/10.4103/jss.jss_59_24multidrug-resistant organismnosocomial infectionsstenotrophomonas maltophilia |
| spellingShingle | Ruchita Gawande Suvarna Sande Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen Journal of the Scientific Society multidrug-resistant organism nosocomial infections stenotrophomonas maltophilia |
| title | Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen |
| title_full | Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen |
| title_fullStr | Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen |
| title_full_unstemmed | Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen |
| title_short | Stenotrophomonas maltophilia – A Threatening Nosocomial Pathogen |
| title_sort | stenotrophomonas maltophilia a threatening nosocomial pathogen |
| topic | multidrug-resistant organism nosocomial infections stenotrophomonas maltophilia |
| url | https://journals.lww.com/10.4103/jss.jss_59_24 |
| work_keys_str_mv | AT ruchitagawande stenotrophomonasmaltophiliaathreateningnosocomialpathogen AT suvarnasande stenotrophomonasmaltophiliaathreateningnosocomialpathogen |