An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease
Abstract Background Alzheimer’s disease (AD) is the commonest worldwide neurodegenerative disorder. Nevertheless, it usually face difficulties to guarantee a secured initial diagnosis. For this reason, neurologists are in dire need for developing potential biomarkers that could be relied upon confid...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-11-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-024-00912-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846158781312925696 |
|---|---|
| author | Ali Ahmed Abou Elmaaty Mona Ali Eissa Shady Elrashedy Hamada Ibrahim Zehry Ahmed Abdulatif Mosa Carmen Ali Zarad Marwa Ahmad Abdel-dayem Amgad Elnokrashy Saad Shawki Elsherifi |
| author_facet | Ali Ahmed Abou Elmaaty Mona Ali Eissa Shady Elrashedy Hamada Ibrahim Zehry Ahmed Abdulatif Mosa Carmen Ali Zarad Marwa Ahmad Abdel-dayem Amgad Elnokrashy Saad Shawki Elsherifi |
| author_sort | Ali Ahmed Abou Elmaaty |
| collection | DOAJ |
| description | Abstract Background Alzheimer’s disease (AD) is the commonest worldwide neurodegenerative disorder. Nevertheless, it usually face difficulties to guarantee a secured initial diagnosis. For this reason, neurologists are in dire need for developing potential biomarkers that could be relied upon confidentially in early diagnosis of AD. Hopefully, this will open the gate for novel modifying therapy to fight with all their might. In this current study, we aimed to correlate plasma levels of tau and Aβ with the changes that occur in hippocampal volume and thickness of retinal fiber layers in patients who clinically diagnosed with AD spectrum. A cross-sectional study enrolled 60 AD patients who fulfilled inclusion and exclusion criteria were subjected to cognitive, radiologic, laboratory and optical coherence tomography (OCT) assessments. Results Tau, Aβ1–40, and Aβ1–40/Aβ1–42 ratio are significant discriminators of AD at cutoff values of >23.45, > 84.4, and > 1.95, respectively. MRI hippocampal volume in both right and left sides are also good discriminators of AD at cutoff values of ≤ 2.997, and ≤ 2.994, respectively. A significant correlations were reported between tau with Aβ1–40, Aβ1–42, MMSE and MRI right and left hippocampal volumes. On comparing moderate versus mild AD, there was a high significant levels of tau, Aβ1–42, Aβ1–40/Aβ1–42 ratio. Conclusions We clarify that several biomarkers could be potentially used for confirming the diagnosis of AD. Assessment of plasma amyloid level, detection of hippocampal atrophy and retinal nerve fiber layer thickness changes are promising tools for early diagnosis of AD. |
| format | Article |
| id | doaj-art-f413e33d7e2e4276a50ef477c21a40c4 |
| institution | Kabale University |
| issn | 1687-8329 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-f413e33d7e2e4276a50ef477c21a40c42024-11-24T12:15:52ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292024-11-0160111610.1186/s41983-024-00912-xAn eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s diseaseAli Ahmed Abou Elmaaty0Mona Ali Eissa1Shady Elrashedy2Hamada Ibrahim Zehry3Ahmed Abdulatif Mosa4Carmen Ali Zarad5Marwa Ahmad Abdel-dayem6Amgad Elnokrashy7Saad Shawki Elsherifi8Neurology, Faculty of Medicine, Badr university hospital, Helwan UniversityNeurology, Faculty of Medicine, Helwan UniversityNeurology, Faculty of Medicine, Delta University for Science and TechnologyNeurology, Faculty of Medicine, Horus UniversityNeurology, Faculty of Medicine, Delta University for Science and TechnologyDiagnostic Radiology, Port Said UniversityClinical Pharmacology, Faculty of pharmacy, Horus UniversityOphthalmology, Mansoura UniversityNeurology, Port Said UniversityAbstract Background Alzheimer’s disease (AD) is the commonest worldwide neurodegenerative disorder. Nevertheless, it usually face difficulties to guarantee a secured initial diagnosis. For this reason, neurologists are in dire need for developing potential biomarkers that could be relied upon confidentially in early diagnosis of AD. Hopefully, this will open the gate for novel modifying therapy to fight with all their might. In this current study, we aimed to correlate plasma levels of tau and Aβ with the changes that occur in hippocampal volume and thickness of retinal fiber layers in patients who clinically diagnosed with AD spectrum. A cross-sectional study enrolled 60 AD patients who fulfilled inclusion and exclusion criteria were subjected to cognitive, radiologic, laboratory and optical coherence tomography (OCT) assessments. Results Tau, Aβ1–40, and Aβ1–40/Aβ1–42 ratio are significant discriminators of AD at cutoff values of >23.45, > 84.4, and > 1.95, respectively. MRI hippocampal volume in both right and left sides are also good discriminators of AD at cutoff values of ≤ 2.997, and ≤ 2.994, respectively. A significant correlations were reported between tau with Aβ1–40, Aβ1–42, MMSE and MRI right and left hippocampal volumes. On comparing moderate versus mild AD, there was a high significant levels of tau, Aβ1–42, Aβ1–40/Aβ1–42 ratio. Conclusions We clarify that several biomarkers could be potentially used for confirming the diagnosis of AD. Assessment of plasma amyloid level, detection of hippocampal atrophy and retinal nerve fiber layer thickness changes are promising tools for early diagnosis of AD.https://doi.org/10.1186/s41983-024-00912-xAlzheimer diseaseTauAmyloidAβ1–40Aβ1–42Retinal nerve fiber layer thickness |
| spellingShingle | Ali Ahmed Abou Elmaaty Mona Ali Eissa Shady Elrashedy Hamada Ibrahim Zehry Ahmed Abdulatif Mosa Carmen Ali Zarad Marwa Ahmad Abdel-dayem Amgad Elnokrashy Saad Shawki Elsherifi An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Alzheimer disease Tau Amyloid Aβ1–40 Aβ1–42 Retinal nerve fiber layer thickness |
| title | An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease |
| title_full | An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease |
| title_fullStr | An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease |
| title_full_unstemmed | An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease |
| title_short | An eye’s look unmasks the mystery: correlation between serum amyloid beta peptide, hippocampal volume and retinal thickness in Alzheimer`s disease |
| title_sort | eye s look unmasks the mystery correlation between serum amyloid beta peptide hippocampal volume and retinal thickness in alzheimer s disease |
| topic | Alzheimer disease Tau Amyloid Aβ1–40 Aβ1–42 Retinal nerve fiber layer thickness |
| url | https://doi.org/10.1186/s41983-024-00912-x |
| work_keys_str_mv | AT aliahmedabouelmaaty aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT monaalieissa aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT shadyelrashedy aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT hamadaibrahimzehry aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT ahmedabdulatifmosa aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT carmenalizarad aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT marwaahmadabdeldayem aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT amgadelnokrashy aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT saadshawkielsherifi aneyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT aliahmedabouelmaaty eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT monaalieissa eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT shadyelrashedy eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT hamadaibrahimzehry eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT ahmedabdulatifmosa eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT carmenalizarad eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT marwaahmadabdeldayem eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT amgadelnokrashy eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease AT saadshawkielsherifi eyeslookunmasksthemysterycorrelationbetweenserumamyloidbetapeptidehippocampalvolumeandretinalthicknessinalzheimersdisease |