Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice
Numerous reports have indicated that the type 3 resistant starch (RS3) derived from <i>Canna edulis</i> can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects. In this study, RS5 was prepared from <i>Canna eduli...
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2025-01-01
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| author | Houxier Li Nan Wang Jiahui Wu Shuting Tan Yan Li Nan Zhang Li Yang Aji Li Rongting Min Maochun Xiao Shiyao Su Xiang Wang Xueyong Wang |
| author_facet | Houxier Li Nan Wang Jiahui Wu Shuting Tan Yan Li Nan Zhang Li Yang Aji Li Rongting Min Maochun Xiao Shiyao Su Xiang Wang Xueyong Wang |
| author_sort | Houxier Li |
| collection | DOAJ |
| description | Numerous reports have indicated that the type 3 resistant starch (RS3) derived from <i>Canna edulis</i> can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects. In this study, RS5 was prepared from <i>Canna edulis</i> native starch and lauric acid through a hydrothermal method for the first time, and its nutritional intervention effects on hyperlipidemia in mice were investigated. The Canna edulis type 5 resistant starch (Ce-RS5) prepared using <i>Canna edulis</i> native starch and lauric acid exhibited a high compound index and resistant starch content, along with decreased swelling power and enhanced starch granule stability. The crystallinity of Ce-RS5 was decreased, and its crystal structure displayed a B+V pattern. Microscopically, the surface appeared rough with deepened grooves, and the granules were loose. Feeding mice with 1.5 g/kg and 3 g/kg of Ce-RS5 significantly reduced their body weight, positively regulated their blood lipid levels, and improved liver damage and fat accumulation. Additionally, Ce-RS5 promoted the abundance of beneficial gut bacteria, such as <i>norank_f_Muribaculaceae</i>, and inhibited the abundance of harmful bacteria like <i>Colidextribacter.</i> This study provides the first evidence of the hypolipidemic and weight loss effects of Ce-RS5 in hyperlipidemia mice. |
| format | Article |
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| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Foods |
| spelling | doaj-art-f40e9b0249a943c49650cdb23183d3ff2025-01-10T13:17:46ZengMDPI AGFoods2304-81582025-01-011419210.3390/foods14010092Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia MiceHouxier Li0Nan Wang1Jiahui Wu2Shuting Tan3Yan Li4Nan Zhang5Li Yang6Aji Li7Rongting Min8Maochun Xiao9Shiyao Su10Xiang Wang11Xueyong Wang12School of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaAir Force Medical Center, No. 30 Fucheng Road, Hai-Dian District, Beijing 100080, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaSchool of Chinese Meteria Medica, Beijing University of Chinese Medicine, Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fang-Shan District, Beijing 102488, ChinaNumerous reports have indicated that the type 3 resistant starch (RS3) derived from <i>Canna edulis</i> can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects. In this study, RS5 was prepared from <i>Canna edulis</i> native starch and lauric acid through a hydrothermal method for the first time, and its nutritional intervention effects on hyperlipidemia in mice were investigated. The Canna edulis type 5 resistant starch (Ce-RS5) prepared using <i>Canna edulis</i> native starch and lauric acid exhibited a high compound index and resistant starch content, along with decreased swelling power and enhanced starch granule stability. The crystallinity of Ce-RS5 was decreased, and its crystal structure displayed a B+V pattern. Microscopically, the surface appeared rough with deepened grooves, and the granules were loose. Feeding mice with 1.5 g/kg and 3 g/kg of Ce-RS5 significantly reduced their body weight, positively regulated their blood lipid levels, and improved liver damage and fat accumulation. Additionally, Ce-RS5 promoted the abundance of beneficial gut bacteria, such as <i>norank_f_Muribaculaceae</i>, and inhibited the abundance of harmful bacteria like <i>Colidextribacter.</i> This study provides the first evidence of the hypolipidemic and weight loss effects of Ce-RS5 in hyperlipidemia mice.https://www.mdpi.com/2304-8158/14/1/92type 5 resistant starchhyperlipidemiagut microbiota |
| spellingShingle | Houxier Li Nan Wang Jiahui Wu Shuting Tan Yan Li Nan Zhang Li Yang Aji Li Rongting Min Maochun Xiao Shiyao Su Xiang Wang Xueyong Wang Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice Foods type 5 resistant starch hyperlipidemia gut microbiota |
| title | Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice |
| title_full | Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice |
| title_fullStr | Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice |
| title_full_unstemmed | Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice |
| title_short | Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice |
| title_sort | characterization and nutritional intervention effects of i canna edulis i type 5 resistant starch in hyperlipidemia mice |
| topic | type 5 resistant starch hyperlipidemia gut microbiota |
| url | https://www.mdpi.com/2304-8158/14/1/92 |
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