Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results
The objective of this work was to investigate the effect on cell viability of radiolabeled complexes of cisplatin and carboplatin in cancer cells of the 4T1 and MDA-MB-231 lines from mice with mammary carcinoma. The complexes were labeled in the CDTN's TRIGA Mark I nuclear research reactor aft...
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| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2025-02-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2614 |
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| author | Alexandre Soares Leal Juliana B Silva Ana Olivia G Morais Brigida Gomes de Almeida Schirmer |
| author_facet | Alexandre Soares Leal Juliana B Silva Ana Olivia G Morais Brigida Gomes de Almeida Schirmer |
| author_sort | Alexandre Soares Leal |
| collection | DOAJ |
| description |
The objective of this work was to investigate the effect on cell viability of radiolabeled complexes of cisplatin and carboplatin in cancer cells of the 4T1 and MDA-MB-231 lines from mice with mammary carcinoma. The complexes were labeled in the CDTN's TRIGA Mark I nuclear research reactor after 3 hours of irradiation. The analyzes were carried out after decay times of 1h and 24h. The results showed a more effective action of cisplatin compared to carboplatin in both cell lines and greater resistance in MDA-MB-231 cells. The additional effect of radiation was more evident in conditions of low resistance. Increasing the final activity of labeled compounds can amplify this effect. Investigations in this regard are underway.
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| format | Article |
| id | doaj-art-f3eb8b10cc74466c9a41ce0eea41cc8d |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-f3eb8b10cc74466c9a41ce0eea41cc8d2025-08-20T03:51:19ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122025-02-0113110.15392/2319-0612.2025.26142239Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary resultsAlexandre Soares Leal0Juliana B Silva1Ana Olivia G Morais2Brigida Gomes de Almeida Schirmer3Centro de Desenvolvimento de Tecnologia Nuclear – CDTN/CNEN. CTDNCentro de Desenvolvimento da Tecnologia Nuclear (CDTN), Av. Antônio Carlos 6.627, Campus da UFMG, Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil. Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Av. Antônio Carlos 6.627, Campus da UFMG, Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil. Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Av. Antônio Carlos 6.627, Campus da UFMG, Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil. The objective of this work was to investigate the effect on cell viability of radiolabeled complexes of cisplatin and carboplatin in cancer cells of the 4T1 and MDA-MB-231 lines from mice with mammary carcinoma. The complexes were labeled in the CDTN's TRIGA Mark I nuclear research reactor after 3 hours of irradiation. The analyzes were carried out after decay times of 1h and 24h. The results showed a more effective action of cisplatin compared to carboplatin in both cell lines and greater resistance in MDA-MB-231 cells. The additional effect of radiation was more evident in conditions of low resistance. Increasing the final activity of labeled compounds can amplify this effect. Investigations in this regard are underway. https://bjrs.org.br/revista/index.php/REVISTA/article/view/2614Cisplatincarboplatinradiochemotherapyantitumoral effects |
| spellingShingle | Alexandre Soares Leal Juliana B Silva Ana Olivia G Morais Brigida Gomes de Almeida Schirmer Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results Brazilian Journal of Radiation Sciences Cisplatin carboplatin radiochemotherapy antitumoral effects |
| title | Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results |
| title_full | Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results |
| title_fullStr | Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results |
| title_full_unstemmed | Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results |
| title_short | Additional radiation effect on cell viability using neutron irradiated Cisplatin and Carboplatin: preliminary results |
| title_sort | additional radiation effect on cell viability using neutron irradiated cisplatin and carboplatin preliminary results |
| topic | Cisplatin carboplatin radiochemotherapy antitumoral effects |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2614 |
| work_keys_str_mv | AT alexandresoaresleal additionalradiationeffectoncellviabilityusingneutronirradiatedcisplatinandcarboplatinpreliminaryresults AT julianabsilva additionalradiationeffectoncellviabilityusingneutronirradiatedcisplatinandcarboplatinpreliminaryresults AT anaoliviagmorais additionalradiationeffectoncellviabilityusingneutronirradiatedcisplatinandcarboplatinpreliminaryresults AT brigidagomesdealmeidaschirmer additionalradiationeffectoncellviabilityusingneutronirradiatedcisplatinandcarboplatinpreliminaryresults |