Acquired hemophilia A: a case report and review of the literature
Abstract Background Acquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnos...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-025-05406-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342567266648064 |
|---|---|
| author | Juan-Alfonso Perotti-Abad Álvaro Cabezas-Corado Luis Astolfi-Labrador María Baus-Domínguez Guillermo Machuca-Portillo María-Ángeles Serrera-Figallo Daniel Torres-Lagares |
| author_facet | Juan-Alfonso Perotti-Abad Álvaro Cabezas-Corado Luis Astolfi-Labrador María Baus-Domínguez Guillermo Machuca-Portillo María-Ángeles Serrera-Figallo Daniel Torres-Lagares |
| author_sort | Juan-Alfonso Perotti-Abad |
| collection | DOAJ |
| description | Abstract Background Acquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnosis in both medical and dental practice. Case presentation We present the clinical case of a 74-year-old Spanish Caucasian patient diagnosed with acquired hemophilia A. The patient was initially treated for progressive edema in the right lower limb, followed by hematomas in the tongue and submandibular region. The diagnosis was confirmed through hematological tests, which revealed a prolonged activated partial thromboplastin time and low coagulation factor VIII activity (2.4%). Treatment with hemostatic agents and corticosteroids was initiated, resulting in a favorable improvement of the hematomas. Conclusions Acquired hemophilia A requires a multidisciplinary and personalized approach for each patient. Focus should be placed on prevention, early diagnosis, and appropriate treatment to effectively manage this coagulopathy and improve patient outcomes. |
| format | Article |
| id | doaj-art-f3e00a7c3bca4504b40caa010de9572f |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-f3e00a7c3bca4504b40caa010de9572f2025-08-20T03:43:21ZengBMCJournal of Medical Case Reports1752-19472025-07-011911810.1186/s13256-025-05406-9Acquired hemophilia A: a case report and review of the literatureJuan-Alfonso Perotti-Abad0Álvaro Cabezas-Corado1Luis Astolfi-Labrador2María Baus-Domínguez3Guillermo Machuca-Portillo4María-Ángeles Serrera-Figallo5Daniel Torres-Lagares6Private Practice at Clínica Dental Juan Alfonso Perotti Abad, C/Doctor MarañónDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/NAbstract Background Acquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnosis in both medical and dental practice. Case presentation We present the clinical case of a 74-year-old Spanish Caucasian patient diagnosed with acquired hemophilia A. The patient was initially treated for progressive edema in the right lower limb, followed by hematomas in the tongue and submandibular region. The diagnosis was confirmed through hematological tests, which revealed a prolonged activated partial thromboplastin time and low coagulation factor VIII activity (2.4%). Treatment with hemostatic agents and corticosteroids was initiated, resulting in a favorable improvement of the hematomas. Conclusions Acquired hemophilia A requires a multidisciplinary and personalized approach for each patient. Focus should be placed on prevention, early diagnosis, and appropriate treatment to effectively manage this coagulopathy and improve patient outcomes.https://doi.org/10.1186/s13256-025-05406-9Hemophilia A acquiredCoagulation disorderFactor VIIIDiagnosisAntibodiesHematoma |
| spellingShingle | Juan-Alfonso Perotti-Abad Álvaro Cabezas-Corado Luis Astolfi-Labrador María Baus-Domínguez Guillermo Machuca-Portillo María-Ángeles Serrera-Figallo Daniel Torres-Lagares Acquired hemophilia A: a case report and review of the literature Journal of Medical Case Reports Hemophilia A acquired Coagulation disorder Factor VIII Diagnosis Antibodies Hematoma |
| title | Acquired hemophilia A: a case report and review of the literature |
| title_full | Acquired hemophilia A: a case report and review of the literature |
| title_fullStr | Acquired hemophilia A: a case report and review of the literature |
| title_full_unstemmed | Acquired hemophilia A: a case report and review of the literature |
| title_short | Acquired hemophilia A: a case report and review of the literature |
| title_sort | acquired hemophilia a a case report and review of the literature |
| topic | Hemophilia A acquired Coagulation disorder Factor VIII Diagnosis Antibodies Hematoma |
| url | https://doi.org/10.1186/s13256-025-05406-9 |
| work_keys_str_mv | AT juanalfonsoperottiabad acquiredhemophiliaaacasereportandreviewoftheliterature AT alvarocabezascorado acquiredhemophiliaaacasereportandreviewoftheliterature AT luisastolfilabrador acquiredhemophiliaaacasereportandreviewoftheliterature AT mariabausdominguez acquiredhemophiliaaacasereportandreviewoftheliterature AT guillermomachucaportillo acquiredhemophiliaaacasereportandreviewoftheliterature AT mariaangelesserrerafigallo acquiredhemophiliaaacasereportandreviewoftheliterature AT danieltorreslagares acquiredhemophiliaaacasereportandreviewoftheliterature |