Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study
Objective. Knee osteoarthritis (KOA) is a progressive joint disorder that significantly impairs patients’ quality of life. Effective long-term management of KOA remains challenging due to limited pharmacological options and associated adverse effects. This monocentric, retrospective observational s...
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PAGEPress Publications
2025-07-01
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| Series: | Reumatismo |
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| Online Access: | https://www.reumatismo.org/reuma/article/view/1872 |
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| author | Alessandro Conforti Cosimo Ruggiero Nastasja Palombi Filippo Messina Marco Bonifacio Linda Lucchetti Marco Ruggiero Giuseppe La Cava Roberto Piazza Mario Mangrella |
| author_facet | Alessandro Conforti Cosimo Ruggiero Nastasja Palombi Filippo Messina Marco Bonifacio Linda Lucchetti Marco Ruggiero Giuseppe La Cava Roberto Piazza Mario Mangrella |
| author_sort | Alessandro Conforti |
| collection | DOAJ |
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Objective. Knee osteoarthritis (KOA) is a progressive joint disorder that significantly impairs patients’ quality of life. Effective long-term management of KOA remains challenging due to limited pharmacological options and associated adverse effects. This monocentric, retrospective observational study evaluated the efficacy and safety of a fixed-dose tramadol/paracetamol combination (75/650 mg) in alleviating pain in patients with grade I-II KOA according to the Kellgren-Lawrence classification.
Methods. A total of 30 patients treated for 15 days were assessed using the Numerical Rating Scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index for functional impairment, and the Pittsburgh Sleep Quality Index for sleep quality.
Results. Results showed a 30% and 50% pain reduction in 86% and 43% of patients, respectively, alongside significant improvements in functional mobility and sleep quality. Adverse events, including nausea, itching, and sleepiness, occurred in 10% of patients and did not necessitate treatment discontinuation. Efficacy was consistent across demographic and clinical subgroups, possibly suggesting broad treatment applicability.
Conclusions. While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research.
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| format | Article |
| id | doaj-art-f3de47dd548b46f0b9cc9c97a7bf730e |
| institution | Kabale University |
| issn | 0048-7449 2240-2683 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | PAGEPress Publications |
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| series | Reumatismo |
| spelling | doaj-art-f3de47dd548b46f0b9cc9c97a7bf730e2025-08-20T03:56:12ZengPAGEPress PublicationsReumatismo0048-74492240-26832025-07-0110.4081/reumatismo.2025.1872Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational studyAlessandro Conforti0Cosimo Ruggiero1Nastasja Palombi2Filippo Messina3Marco Bonifacio4Linda Lucchetti5Marco Ruggiero6Giuseppe La Cava7Roberto Piazza8Mario Mangrella9Local Health Rheumatology Unit, San Paolo Hospital, ASL Roma 4, RomePediatric Gastroenterology Unit, Policlinico Umberto I, RomeMedical Affairs Department, Italfarmaco SpA, MilanRadiology Unit, ASL Roma 4, RomeCivitavecchia, RomeHospital Pharmacy Unit, ASL Roma 4, RomeIOR – Complex Structure of Orthopedics and Traumatology, Rizzoli-Argenta, BolognaDivision of Orthopedic Surgery, San Paolo Hospital, CivitavecchiaMedical Affairs Department, Italfarmaco SpA, MilanMedical Affairs Department, Italfarmaco SpA, Milan Objective. Knee osteoarthritis (KOA) is a progressive joint disorder that significantly impairs patients’ quality of life. Effective long-term management of KOA remains challenging due to limited pharmacological options and associated adverse effects. This monocentric, retrospective observational study evaluated the efficacy and safety of a fixed-dose tramadol/paracetamol combination (75/650 mg) in alleviating pain in patients with grade I-II KOA according to the Kellgren-Lawrence classification. Methods. A total of 30 patients treated for 15 days were assessed using the Numerical Rating Scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index for functional impairment, and the Pittsburgh Sleep Quality Index for sleep quality. Results. Results showed a 30% and 50% pain reduction in 86% and 43% of patients, respectively, alongside significant improvements in functional mobility and sleep quality. Adverse events, including nausea, itching, and sleepiness, occurred in 10% of patients and did not necessitate treatment discontinuation. Efficacy was consistent across demographic and clinical subgroups, possibly suggesting broad treatment applicability. Conclusions. While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research. https://www.reumatismo.org/reuma/article/view/1872Knee osteoarthritistramadol/paracetamolnumerical rating scaleWOMAC Osteoarthritis IndexPittsburgh Sleep Quality Index |
| spellingShingle | Alessandro Conforti Cosimo Ruggiero Nastasja Palombi Filippo Messina Marco Bonifacio Linda Lucchetti Marco Ruggiero Giuseppe La Cava Roberto Piazza Mario Mangrella Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study Reumatismo Knee osteoarthritis tramadol/paracetamol numerical rating scale WOMAC Osteoarthritis Index Pittsburgh Sleep Quality Index |
| title | Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study |
| title_full | Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study |
| title_fullStr | Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study |
| title_full_unstemmed | Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study |
| title_short | Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study |
| title_sort | evaluation of tramadol paracetamol 75 mg 650 mg combination therapy for early stage knee osteoarthritis a retrospective observational study |
| topic | Knee osteoarthritis tramadol/paracetamol numerical rating scale WOMAC Osteoarthritis Index Pittsburgh Sleep Quality Index |
| url | https://www.reumatismo.org/reuma/article/view/1872 |
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