Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients
We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosilate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zeste homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetosta...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/mjhid/article/view/5485 |
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| _version_ | 1841564507924594688 |
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| author | Gianmarco Bagnato Vittorio Stefoni Alessandro Broccoli Lisa Argnani Cinzia Pellegrini Beatrice Casadei Francesca Bonifazi Pier Luigi Zinzani |
| author_facet | Gianmarco Bagnato Vittorio Stefoni Alessandro Broccoli Lisa Argnani Cinzia Pellegrini Beatrice Casadei Francesca Bonifazi Pier Luigi Zinzani |
| author_sort | Gianmarco Bagnato |
| collection | DOAJ |
| description |
We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosilate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zeste homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetostat led to a quick response and was well tolerated, offering as a promising bridge therapy to transplantation for patients with relapsed/refractory peripheral T-cell lymphoma which is still an unmet medical need.
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| format | Article |
| id | doaj-art-f3bcfe6454db4c48926e6d674464f884 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-f3bcfe6454db4c48926e6d674464f8842025-01-02T22:43:29ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062024-01-0116110.4084/MJHID.2024.004Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patientsGianmarco BagnatoVittorio StefoniAlessandro BroccoliLisa ArgnaniCinzia PellegriniBeatrice CasadeiFrancesca BonifaziPier Luigi Zinzani0a:1:{s:5:"en_US";s:71:"Institute of Hematology “L. e A. Seràgnoli”, University of Bologna";} We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosilate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zeste homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetostat led to a quick response and was well tolerated, offering as a promising bridge therapy to transplantation for patients with relapsed/refractory peripheral T-cell lymphoma which is still an unmet medical need. https://mjhid.org/mjhid/article/view/5485ValemetostatPeripheral T-cell LymphomaAllogeneic TransplantationRefractory Disease |
| spellingShingle | Gianmarco Bagnato Vittorio Stefoni Alessandro Broccoli Lisa Argnani Cinzia Pellegrini Beatrice Casadei Francesca Bonifazi Pier Luigi Zinzani Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients Mediterranean Journal of Hematology and Infectious Diseases Valemetostat Peripheral T-cell Lymphoma Allogeneic Transplantation Refractory Disease |
| title | Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients |
| title_full | Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients |
| title_fullStr | Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients |
| title_full_unstemmed | Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients |
| title_short | Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients |
| title_sort | successful bridging to allogeneic transplantation with valemetostat in two refractory relapsed peripheral t cell lymphoma patients |
| topic | Valemetostat Peripheral T-cell Lymphoma Allogeneic Transplantation Refractory Disease |
| url | https://mjhid.org/mjhid/article/view/5485 |
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