Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure
During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and...
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| Format: | Article |
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Dnipro State Medical University
2021-06-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://journals.uran.ua/index.php/2307-0404/article/view/234498 |
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| author | O.V. Fedosieieva |
| author_facet | O.V. Fedosieieva |
| author_sort | O.V. Fedosieieva |
| collection | DOAJ |
| description | During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and ideas about its structural and functional restructuring in response to the body's immune system to various infections. The morpho-functional features of the thyroid gland of newborn animals after prenatal action of thyroid-nonspecific antigen (staphylococcal toxoid) have been experimentally established. In antigen-premiumed rats, the timing of folliculogenesis changes, as well as the size, distribution and immunohistochemical expression of antibodies to thyroglobulin, the functional state of thyrocytes and follicles compared to normal. The detected immunohistochemical changes indicate signs of morpho-functional immaturity of the organ with hypoactivity elements. |
| format | Article |
| id | doaj-art-f3ae5715ea6944d08375a1f6b955660a |
| institution | Kabale University |
| issn | 2307-0404 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-f3ae5715ea6944d08375a1f6b955660a2024-12-02T00:03:11ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042021-06-01262404510.26641/2307-0404.2021.2.234498272161Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposureO.V. Fedosieieva0https://orcid.org/0000-0003-2247-1965Zaporizhzhia State Medical University, Department of Histology, Cytology and Embryology, Maiakovskoho av., 26, Zaporizhzhia, 69035, UkraineDuring the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and ideas about its structural and functional restructuring in response to the body's immune system to various infections. The morpho-functional features of the thyroid gland of newborn animals after prenatal action of thyroid-nonspecific antigen (staphylococcal toxoid) have been experimentally established. In antigen-premiumed rats, the timing of folliculogenesis changes, as well as the size, distribution and immunohistochemical expression of antibodies to thyroglobulin, the functional state of thyrocytes and follicles compared to normal. The detected immunohistochemical changes indicate signs of morpho-functional immaturity of the organ with hypoactivity elements.http://journals.uran.ua/index.php/2307-0404/article/view/234498thyroglobulinthyroid glandratsantigen |
| spellingShingle | O.V. Fedosieieva Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure Medičnì Perspektivi thyroglobulin thyroid gland rats antigen |
| title | Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| title_full | Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| title_fullStr | Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| title_full_unstemmed | Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| title_short | Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| title_sort | immune histochemical indicators of the morpho functional state of the thyroid gland in norm and after prenatal antigenic exposure |
| topic | thyroglobulin thyroid gland rats antigen |
| url | http://journals.uran.ua/index.php/2307-0404/article/view/234498 |
| work_keys_str_mv | AT ovfedosieieva immunehistochemicalindicatorsofthemorphofunctionalstateofthethyroidglandinnormandafterprenatalantigenicexposure |