Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study
Introduction: Diabetic kidney disease (DKD) progression resulted in increased intrarenal oxidative stress and increased inflammatory resulting in further renal fibrosis. Achatina fulica mucus was regarded to exerts anti-oxidative and anti-inflammatory effect. Objectives: This study aims to observe t...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2024-08-01
|
| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-13-e21465.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846141561038962688 |
|---|---|
| author | Wachid Putranto Gigih Fitriawan Ratih Tri Kusuma Dewi Aryo Suseno Arief Nurudhin Yulyani Werdiningsih Santy Ayu Puspita Perdhana Nurhasan Agung Prabowo Yeremia Suryo Pratama |
| author_facet | Wachid Putranto Gigih Fitriawan Ratih Tri Kusuma Dewi Aryo Suseno Arief Nurudhin Yulyani Werdiningsih Santy Ayu Puspita Perdhana Nurhasan Agung Prabowo Yeremia Suryo Pratama |
| author_sort | Wachid Putranto |
| collection | DOAJ |
| description | Introduction: Diabetic kidney disease (DKD) progression resulted in increased intrarenal oxidative stress and increased inflammatory resulting in further renal fibrosis. Achatina fulica mucus was regarded to exerts anti-oxidative and anti-inflammatory effect. Objectives: This study aims to observe the effect of administration of A. fulica mucus on oxidative stress and inflammation biomarkers in DKD-induced rats. Methods and Materials: In this study, we used 32 males white Wistar rats divided into four groups; a control, and other three different groups induced with 45 mg/kg streptozocin (STZ) and 110 mg/kg nicotinamide (NA) intra-peritoneally. Achatina fulica mucus was administered orally in the last groups; 3.5 mL/d (S1), and 7 mL/d (S2). Post-test measurement of inflammatory and oxidative biomarker was used to determine the outcome. Results: The study resulted in reduction of malondialdehyde (MDA), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), high sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF), and interleukin-1β (IL-1β) in A. fulica mucus administration in our STZ-NA induced rats, with higher dose of the mucus further reduce the inflammatory and oxidative stress biomarkers. Conclusion: Current study showed the potential of A. fulica mucus usage in future management of inflammation and oxidative stress in diabetes and DKD. |
| format | Article |
| id | doaj-art-f3a16c7b42644fd8a670d489760617a8 |
| institution | Kabale University |
| issn | 2251-8363 2251-8819 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj-art-f3a16c7b42644fd8a670d489760617a82024-12-04T06:46:20ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192024-08-01134e21465e2146510.34172/jnp.2023.21465jnp-21465Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model studyWachid Putranto0Gigih Fitriawan1Ratih Tri Kusuma Dewi2Aryo Suseno3Arief Nurudhin4Yulyani Werdiningsih5Santy Ayu Puspita Perdhana6Nurhasan Agung Prabowo7Yeremia Suryo Pratama8Faculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaIntroduction: Diabetic kidney disease (DKD) progression resulted in increased intrarenal oxidative stress and increased inflammatory resulting in further renal fibrosis. Achatina fulica mucus was regarded to exerts anti-oxidative and anti-inflammatory effect. Objectives: This study aims to observe the effect of administration of A. fulica mucus on oxidative stress and inflammation biomarkers in DKD-induced rats. Methods and Materials: In this study, we used 32 males white Wistar rats divided into four groups; a control, and other three different groups induced with 45 mg/kg streptozocin (STZ) and 110 mg/kg nicotinamide (NA) intra-peritoneally. Achatina fulica mucus was administered orally in the last groups; 3.5 mL/d (S1), and 7 mL/d (S2). Post-test measurement of inflammatory and oxidative biomarker was used to determine the outcome. Results: The study resulted in reduction of malondialdehyde (MDA), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), high sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF), and interleukin-1β (IL-1β) in A. fulica mucus administration in our STZ-NA induced rats, with higher dose of the mucus further reduce the inflammatory and oxidative stress biomarkers. Conclusion: Current study showed the potential of A. fulica mucus usage in future management of inflammation and oxidative stress in diabetes and DKD.https://nephropathol.com/PDF/jnp-13-e21465.pdfdiabetesdiabetic nephropathyinflammationoxidative stress |
| spellingShingle | Wachid Putranto Gigih Fitriawan Ratih Tri Kusuma Dewi Aryo Suseno Arief Nurudhin Yulyani Werdiningsih Santy Ayu Puspita Perdhana Nurhasan Agung Prabowo Yeremia Suryo Pratama Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study Journal of Nephropathology diabetes diabetic nephropathy inflammation oxidative stress |
| title | Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study |
| title_full | Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study |
| title_fullStr | Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study |
| title_full_unstemmed | Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study |
| title_short | Anti-oxidative and anti-inflammatory activity of Achatina fulica mucus in streptozocin-nicotinamide-induced diabetic kidney disease: an animal model study |
| title_sort | anti oxidative and anti inflammatory activity of achatina fulica mucus in streptozocin nicotinamide induced diabetic kidney disease an animal model study |
| topic | diabetes diabetic nephropathy inflammation oxidative stress |
| url | https://nephropathol.com/PDF/jnp-13-e21465.pdf |
| work_keys_str_mv | AT wachidputranto antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT gigihfitriawan antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT ratihtrikusumadewi antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT aryosuseno antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT ariefnurudhin antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT yulyaniwerdiningsih antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT santyayupuspitaperdhana antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT nurhasanagungprabowo antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy AT yeremiasuryopratama antioxidativeandantiinflammatoryactivityofachatinafulicamucusinstreptozocinnicotinamideinduceddiabetickidneydiseaseananimalmodelstudy |