A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation

Abstract Peptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. PADI4 additionally mediates immune responses and cellular reprogramming, although the full extent of its physiological roles is unexplo...

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Main Authors: M. Teresa Bertran, Robert Walmsley, Thomas Cummings, Iker Valle Aramburu, Donald J. Benton, Rocio Mora Molina, Jayalini Assalaarachchi, Maria Chasampalioti, Tessa Swanton, Dhira Joshi, Stefania Federico, Hanneke Okkenhaug, Lu Yu, David Oxley, Simon Walker, Venizelos Papayannopoulos, Hiroaki Suga, Maria A. Christophorou, Louise J. Walport
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53554-1
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