Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria
Background. Elevated endothelial activation markers are linked to malaria syndromes due to the sequestration of Plasmodium falciparum-infected red blood cells in deep tissue vessels. This study evaluated vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) level...
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Universidad Nacional Hermilio Valdizán de Huánuco
2024-12-01
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| Series: | Microbes, Infection and Chemotherapy |
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| Online Access: | https://revistas.unheval.edu.pe/index.php/mic/article/view/2246 |
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| author | Uche T. Igbasi Wellington A. Oyibo |
| author_facet | Uche T. Igbasi Wellington A. Oyibo |
| author_sort | Uche T. Igbasi |
| collection | DOAJ |
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Background. Elevated endothelial activation markers are linked to malaria syndromes due to the sequestration of Plasmodium falciparum-infected red blood cells in deep tissue vessels. This study evaluated vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) levels in uncomplicated malaria and their association with host factors. Methods. A cross-sectional study was conducted in four health facilities in Ikorodu, Lagos State, Nigeria. Blood samples from children and adults were screened for malaria via microscopy, and plasma ICAM-1 and VCAM-1 levels were measured using ELISA. Results. ICAM-1 (1.03 × 106 ± 20,689.2 pg/ml) and VCAM-1 (1.11 × 106 pg/ml; range: 3,725–6,273,725 pg/ml) levels were significantly higher in malaria-positive cases compared to controls (p < 0.01). The geometric mean parasite density was 11,183 parasites/μl, but ICAM-1 and VCAM-1 levels did not correlate with parasite density (p > 0.1). Packed cell volume (PCV) was significantly lower in malaria-positive cases (p = 0.042), with ICAM-1 and VCAM-1 negatively correlating with PCV (p < 0.05). Both markers were also inversely associated with age (p < 0.05). Conclusion. VCAM-1 and ICAM-1 levels are elevated in uncomplicated malaria, independent of parasite density but negatively associated with PCV and age, highlighting the role of endothelial activation in malaria pathology.
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| format | Article |
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| institution | Kabale University |
| issn | 2789-4274 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universidad Nacional Hermilio Valdizán de Huánuco |
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| series | Microbes, Infection and Chemotherapy |
| spelling | doaj-art-f38ed544012c4da99e4b4218ebb68fd02025-01-04T14:53:45ZengUniversidad Nacional Hermilio Valdizán de HuánucoMicrobes, Infection and Chemotherapy2789-42742024-12-01410.54034/mic.e2246Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, NigeriaUche T. Igbasi0Wellington A. Oyibo1Centre for Infectious Diseases Research, Microbiology Department, Nigerian Institute of Medical Research, 6 Edmund Crescent, Yaba - Lagos, NigeriaCentre for Transdisciplinary Research in Malaria/ANDI Centre of Excellence for Malaria Diagnosis, College of Medicine, University of Lagos, Lagos, Nigeria Background. Elevated endothelial activation markers are linked to malaria syndromes due to the sequestration of Plasmodium falciparum-infected red blood cells in deep tissue vessels. This study evaluated vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) levels in uncomplicated malaria and their association with host factors. Methods. A cross-sectional study was conducted in four health facilities in Ikorodu, Lagos State, Nigeria. Blood samples from children and adults were screened for malaria via microscopy, and plasma ICAM-1 and VCAM-1 levels were measured using ELISA. Results. ICAM-1 (1.03 × 106 ± 20,689.2 pg/ml) and VCAM-1 (1.11 × 106 pg/ml; range: 3,725–6,273,725 pg/ml) levels were significantly higher in malaria-positive cases compared to controls (p < 0.01). The geometric mean parasite density was 11,183 parasites/μl, but ICAM-1 and VCAM-1 levels did not correlate with parasite density (p > 0.1). Packed cell volume (PCV) was significantly lower in malaria-positive cases (p = 0.042), with ICAM-1 and VCAM-1 negatively correlating with PCV (p < 0.05). Both markers were also inversely associated with age (p < 0.05). Conclusion. VCAM-1 and ICAM-1 levels are elevated in uncomplicated malaria, independent of parasite density but negatively associated with PCV and age, highlighting the role of endothelial activation in malaria pathology. https://revistas.unheval.edu.pe/index.php/mic/article/view/2246uncomplicated malariaendothelial adhesion moleculesICAM-1VCAM-1 |
| spellingShingle | Uche T. Igbasi Wellington A. Oyibo Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria Microbes, Infection and Chemotherapy uncomplicated malaria endothelial adhesion molecules ICAM-1 VCAM-1 |
| title | Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria |
| title_full | Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria |
| title_fullStr | Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria |
| title_full_unstemmed | Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria |
| title_short | Endothelial molecule levels (VCAM-1, ICAM-1) in uncomplicated malaria cases in Lagos, Nigeria |
| title_sort | endothelial molecule levels vcam 1 icam 1 in uncomplicated malaria cases in lagos nigeria |
| topic | uncomplicated malaria endothelial adhesion molecules ICAM-1 VCAM-1 |
| url | https://revistas.unheval.edu.pe/index.php/mic/article/view/2246 |
| work_keys_str_mv | AT uchetigbasi endothelialmoleculelevelsvcam1icam1inuncomplicatedmalariacasesinlagosnigeria AT wellingtonaoyibo endothelialmoleculelevelsvcam1icam1inuncomplicatedmalariacasesinlagosnigeria |