Life’s Crucial 9 score and chronic kidney disease: insights from NHANES 2005–2018 and the mediating role of systemic inflammation and oxidative stress

Life’s Crucial 9 score and chronic kidney disease: insights from NHANES 2005–2018 and the mediating role of systemic inflammation and oxidative stress

BackgroundChronic kidney disease (CKD) is a growing global health burden, closely linked to metabolic and cardiovascular risk factors. Life’s Crucial 9 (LC9) is a novel health assessment tool that expands upon Life’s Essential 8 (LE8) by incorporating mental health (depression) as a key component. T...

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Bibliographic Details
Main Authors: Shiyuan Qin, Jin Yang, Zili Wang, Pinglin He, Taotao Dong, Zhengyun Ren, Qiuyang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
CKD
LC9
LE8
mediation analysis
NHANES
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1605931/full
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