A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications
Hydrogels have emerged as a promising class of biomaterials for drug delivery applications due to their unique physicochemical properties, including high water content, soft and rubbery texture, and ability to encapsulate and release therapeutic agents in a controlled manner. This review article pro...
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| Format: | Article |
| Language: | English |
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Iranian Chemical Society
2024-10-01
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| Series: | Nanochemistry Research |
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| Online Access: | http://www.nanochemres.org/article_206449_425988d50e857465198cba46927466db.pdf |
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| author | Azadeh Asefnejad Nesa Rastgoo Shirin Ardeshiriansharifabadi Samira Basir Shabestari Tohid Khodadadi Foad Iranmanesh |
| author_facet | Azadeh Asefnejad Nesa Rastgoo Shirin Ardeshiriansharifabadi Samira Basir Shabestari Tohid Khodadadi Foad Iranmanesh |
| author_sort | Azadeh Asefnejad |
| collection | DOAJ |
| description | Hydrogels have emerged as a promising class of biomaterials for drug delivery applications due to their unique physicochemical properties, including high water content, soft and rubbery texture, and ability to encapsulate and release therapeutic agents in a controlled manner. This review article provides a comprehensive overview of the synthesis, types, and applications of hydrogels in various organs of the body for drug delivery. The article first discusses different methods of hydrogel synthesis, including physical, chemical, and enzymatic crosslinking techniques, and how these influence the final properties of the hydrogel. It then categorizes hydrogels based on their source (natural or synthetic), responsiveness to stimuli (e.g., pH, temperature, light), and structural characteristics (e.g., interpenetrating networks, hybrid hydrogels). The article subsequently explores the utilization of hydrogels for drug delivery in diverse anatomical locations, such as the skin, eyes, nasal and oral cavities, gastrointestinal (GI) tract, and cardiovascular system. It shows how the unique features of hydrogels, such as high biocompatibility, tunable degradation kinetics, and the ability to incorporate various therapeutic agents, making them well-suited for targeted and controlled drug release in these organs. Finally, the article discusses the current challenges and future prospects in the field of hydrogel-based drug delivery systems (DDS), including the need for advanced characterization techniques, scale-up manufacturing, and clinical translation. This article represents a valuable resource for researchers, clinicians, and pharmaceutical scientists interested in leveraging the potential of hydrogels for innovative drug delivery solutions. |
| format | Article |
| id | doaj-art-f35e9062169a4167b61f30d6f487e565 |
| institution | Kabale University |
| issn | 2538-4279 2423-818X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Iranian Chemical Society |
| record_format | Article |
| series | Nanochemistry Research |
| spelling | doaj-art-f35e9062169a4167b61f30d6f487e5652025-01-12T10:25:19ZengIranian Chemical SocietyNanochemistry Research2538-42792423-818X2024-10-019430131510.22036/NCR.2024.04.06206449A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific ApplicationsAzadeh Asefnejad0Nesa Rastgoo1Shirin Ardeshiriansharifabadi2Samira Basir Shabestari3Tohid Khodadadi4Foad Iranmanesh5Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of ENT and Head and Neck, Firoozgar Hospital, School of Medicine, ENT and Head and Neck Research Center, Iran University of Medical Sciences, Tehran, IranGraduate Student, Dental Students’ Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranEndodontic Department, Dental school, Rafsanjan University of Medical Sciences, Rafsanjan, IranHydrogels have emerged as a promising class of biomaterials for drug delivery applications due to their unique physicochemical properties, including high water content, soft and rubbery texture, and ability to encapsulate and release therapeutic agents in a controlled manner. This review article provides a comprehensive overview of the synthesis, types, and applications of hydrogels in various organs of the body for drug delivery. The article first discusses different methods of hydrogel synthesis, including physical, chemical, and enzymatic crosslinking techniques, and how these influence the final properties of the hydrogel. It then categorizes hydrogels based on their source (natural or synthetic), responsiveness to stimuli (e.g., pH, temperature, light), and structural characteristics (e.g., interpenetrating networks, hybrid hydrogels). The article subsequently explores the utilization of hydrogels for drug delivery in diverse anatomical locations, such as the skin, eyes, nasal and oral cavities, gastrointestinal (GI) tract, and cardiovascular system. It shows how the unique features of hydrogels, such as high biocompatibility, tunable degradation kinetics, and the ability to incorporate various therapeutic agents, making them well-suited for targeted and controlled drug release in these organs. Finally, the article discusses the current challenges and future prospects in the field of hydrogel-based drug delivery systems (DDS), including the need for advanced characterization techniques, scale-up manufacturing, and clinical translation. This article represents a valuable resource for researchers, clinicians, and pharmaceutical scientists interested in leveraging the potential of hydrogels for innovative drug delivery solutions.http://www.nanochemres.org/article_206449_425988d50e857465198cba46927466db.pdftargeted drug deliverycontrolled drug releasehydrogel propertiesstimuli-responsive mechanismsbiopolymer formulations |
| spellingShingle | Azadeh Asefnejad Nesa Rastgoo Shirin Ardeshiriansharifabadi Samira Basir Shabestari Tohid Khodadadi Foad Iranmanesh A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications Nanochemistry Research targeted drug delivery controlled drug release hydrogel properties stimuli-responsive mechanisms biopolymer formulations |
| title | A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications |
| title_full | A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications |
| title_fullStr | A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications |
| title_full_unstemmed | A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications |
| title_short | A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications |
| title_sort | brief review of hydrogels for drug delivery for different organs of the body synthesis categorization and organ specific applications |
| topic | targeted drug delivery controlled drug release hydrogel properties stimuli-responsive mechanisms biopolymer formulations |
| url | http://www.nanochemres.org/article_206449_425988d50e857465198cba46927466db.pdf |
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