Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis
Background/Aims The assessment of liver fibrosis is crucial for managing autoimmune liver diseases such as primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). However, data on the efficacy of noninvasive tests for these diseases are limited. This...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2024-09-01
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| Series: | Clinical and Molecular Hepatology |
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| Online Access: | http://e-cmh.org/upload/pdf/cmh-2024-0586.pdf |
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| author | Jihyun An Young Eun Chon Gunho Kim Mi Na Kim Hee Yeon Kim Han Ah Lee Jung Hwan Yu Miyoung Choi Dae Won Jun Seung Up Kim Ji Won Han Young-Joo Jin |
| author_facet | Jihyun An Young Eun Chon Gunho Kim Mi Na Kim Hee Yeon Kim Han Ah Lee Jung Hwan Yu Miyoung Choi Dae Won Jun Seung Up Kim Ji Won Han Young-Joo Jin |
| author_sort | Jihyun An |
| collection | DOAJ |
| description | Background/Aims The assessment of liver fibrosis is crucial for managing autoimmune liver diseases such as primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). However, data on the efficacy of noninvasive tests for these diseases are limited. This meta-analysis evaluated the diagnostic accuracy of vibration-controlled transient elastography (VCTE) for staging fibrosis in patients with autoimmune liver disease. Methods Searches were conducted in PubMed, Embase, CINAHL, Web of Science, and Cochrane Library databases to assess the diagnostic accuracy of VCTE against histology as the reference standard in adult patients with autoimmune liver disease. The summary area under the curve (sAUC) and diagnostic odds ratio were calculated for significant fibrosis (SF), advanced fibrosis (AF), and cirrhosis, according to liver biopsy. Results Fourteen articles were included, comprising 559 PBC patients from six studies, 388 AIH patients from five studies, and 151 PSC patients from three studies. VCTE demonstrated good performance for fibrosis staging in PBC, AIH, and PSC. In PBC, sAUCs of VCTE were 0.87, 0.89, and 0.99 for staging SF, AF, and cirrhosis, respectively. In AIH, the sAUCs were 0.88, 0.88, and 0.92, respectively, while in PSC, they were 0.88, 0.95, and 0.92, respectively. The cutoff values for AF were 7.5–17.9 kPa in PBC, 8.18–12.1 kPa in AIH, and 9.6 kPa in PSC. Conclusions VCTE shows high diagnostic accuracy for staging liver fibrosis in patients with autoimmune liver diseases. This non-invasive method serves as a valuable tool for the evaluation and monitoring of fibrosis in these lifelong diseases. |
| format | Article |
| id | doaj-art-f34ee13411b4400e927e89cb8c35a811 |
| institution | Kabale University |
| issn | 2287-2728 2287-285X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj-art-f34ee13411b4400e927e89cb8c35a8112024-11-19T00:30:07ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2024-09-0130SupplS134S14610.3350/cmh.2024.05862017Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysisJihyun An0Young Eun Chon1Gunho Kim2Mi Na Kim3Hee Yeon Kim4Han Ah Lee5Jung Hwan Yu6Miyoung Choi7Dae Won Jun8Seung Up Kim9Ji Won Han10Young-Joo Jin11 Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea Department of Internal Medicine, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea Division of Health Technology Assessment Research, National EvidenceBased Healthcare Collaborating Agency (NECA), Seoul, Korea Department of Gastroenterology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, KoreaBackground/Aims The assessment of liver fibrosis is crucial for managing autoimmune liver diseases such as primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC). However, data on the efficacy of noninvasive tests for these diseases are limited. This meta-analysis evaluated the diagnostic accuracy of vibration-controlled transient elastography (VCTE) for staging fibrosis in patients with autoimmune liver disease. Methods Searches were conducted in PubMed, Embase, CINAHL, Web of Science, and Cochrane Library databases to assess the diagnostic accuracy of VCTE against histology as the reference standard in adult patients with autoimmune liver disease. The summary area under the curve (sAUC) and diagnostic odds ratio were calculated for significant fibrosis (SF), advanced fibrosis (AF), and cirrhosis, according to liver biopsy. Results Fourteen articles were included, comprising 559 PBC patients from six studies, 388 AIH patients from five studies, and 151 PSC patients from three studies. VCTE demonstrated good performance for fibrosis staging in PBC, AIH, and PSC. In PBC, sAUCs of VCTE were 0.87, 0.89, and 0.99 for staging SF, AF, and cirrhosis, respectively. In AIH, the sAUCs were 0.88, 0.88, and 0.92, respectively, while in PSC, they were 0.88, 0.95, and 0.92, respectively. The cutoff values for AF were 7.5–17.9 kPa in PBC, 8.18–12.1 kPa in AIH, and 9.6 kPa in PSC. Conclusions VCTE shows high diagnostic accuracy for staging liver fibrosis in patients with autoimmune liver diseases. This non-invasive method serves as a valuable tool for the evaluation and monitoring of fibrosis in these lifelong diseases.http://e-cmh.org/upload/pdf/cmh-2024-0586.pdfliver fibrosistransient elastographyautoimmune diseasenoninvasive test |
| spellingShingle | Jihyun An Young Eun Chon Gunho Kim Mi Na Kim Hee Yeon Kim Han Ah Lee Jung Hwan Yu Miyoung Choi Dae Won Jun Seung Up Kim Ji Won Han Young-Joo Jin Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis Clinical and Molecular Hepatology liver fibrosis transient elastography autoimmune disease noninvasive test |
| title | Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis |
| title_full | Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis |
| title_fullStr | Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis |
| title_short | Diagnostic accuracy of vibration-controlled transient elastography for staging liver fibrosis in autoimmune liver diseases: A systematic review and meta-analysis |
| title_sort | diagnostic accuracy of vibration controlled transient elastography for staging liver fibrosis in autoimmune liver diseases a systematic review and meta analysis |
| topic | liver fibrosis transient elastography autoimmune disease noninvasive test |
| url | http://e-cmh.org/upload/pdf/cmh-2024-0586.pdf |
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