3-Deoxysappanchalcone Inhibited High Mobility Group Box Protein 1-Mediated Severe Inflammatory Responses

3-Deoxysappanchalcone Inhibited High Mobility Group Box Protein 1-Mediated Severe Inflammatory Responses

<b>Background/Objectives:</b> Phytochemicals are increasingly recognized for their therapeutic potential in treating various diseases, including vascular disorders. High mobility group box 1 (HMGB1), a key mediator of late-stage sepsis, triggers the release of proinflammatory cytokines,...

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Bibliographic Details
Main Authors: Jinhee Lee, Gyuri Han, Jong-Sup Bae
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
3-deoxysappanchalcone
barrier integrity
LPS
HMGB1
endothelium
Online Access:https://www.mdpi.com/1424-8247/18/5/731
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