Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

Abstract Background Parkinson's disease (PD) is a sporadic neurodegenerative disorder with a rising incidence. Environmental toxins are considered the main etiological factor. The increasing use of polystyrene nanoparticles (PS-NPs) has raised concerns about their potential neurotoxic effects i...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaomei Liang, Yaqi Zeng, Piao Zhang, Baoyu Zhu, Jiezhu Feng, Tongtong Deng, Zhongling Fu, Chengshuai Liu, Chengyu Chen, Yuhu Zhang
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Series:	Journal of Translational Medicine
Subjects:	Polystyrene nanoplastics (PS-NPs) Parkinson’s disease (PD) Pyroptosis Tuberous Sclerosis Complex 2 protein (TSC2) Autophagosome-lysosome fusion
Online Access:	https://doi.org/10.1186/s12967-025-06634-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

Similar Items