Evaluation of Complete Blood Count Parameters to Predict Abnormal Uterine Bleeding
<b>Background/Objectives:</b> To investigate the diagnostic value of hematological parameters in adolescents with abnormal uterine bleeding (AUB), to make early diagnoses, and to prevent life-threatening bleeding. <b>Methods</b>: A total of 141 children, 70 patients, and 71 c...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/12/3/327 |
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| Summary: | <b>Background/Objectives:</b> To investigate the diagnostic value of hematological parameters in adolescents with abnormal uterine bleeding (AUB), to make early diagnoses, and to prevent life-threatening bleeding. <b>Methods</b>: A total of 141 children, 70 patients, and 71 controls were included in the study. The laboratory findings of the patient and control groups were obtained from medical records. Cut-off values were estimated using constructing receiver operating characteristic (ROC) curves of complete blood count parameters to differentiate patients with AUB from control patients. <b>Results</b>: WBC, neutrophil, eosinophil, neutrophil/lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), CRP/albumin ratio, CRP, albumin, PDW, RDW, MPV, and APTT were higher in the AUB group compared to the control group (<i>p</i> = 0.010, <i>p</i> = 0.002, <i>p</i> = 0.017, <i>p</i> = 0.017, <i>p</i> = 0.005, <i>p</i> = 0.003, and <i>p</i> < 0.001, respectively). Erythrocytes, hemoglobin, hematocrit, MCV, MCH, MCHC, fibrinogen, and INR were lower in the AUB group than in the control group (<i>p</i> < 0.001 for all). According to ROC analysis, RDW showed the highest diagnostic performance, with an AUC of 0.999 (<i>p</i> < 0.001). PDW and MPV also demonstrated high diagnostic values (AUC = 0.995 and AUC = 0.928, respectively) (<i>p</i> < 0.001). The NLR, SIRI, and CRP/albumin ratio had moderate diagnostic efficacy, with AUC values of 0.612, 0.640, and 0.642 (<i>p</i> = 0.022, <i>p</i> = 0.004, and <i>p</i> = 0.004, respectively). <b>Conclusions</b>: The high diagnostic performance of parameters such as RDW, PDW, and MPV in diagnosing AUB indicates that these parameters should be considered in clinical applications. |
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| ISSN: | 2227-9067 |