Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model.

Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model.

<h4>Background</h4>Alpha-1 antitrypsin deficiency (AATD) is an inherited disease, the common variant caused by a Pi*Z mutation in the SERPINA1 gene. Pi*Z AAT increases the risk of pulmonary emphysema and liver disease. Berberine (BBR) is a nature dietary supplement and herbal remedy. Eme...

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Bibliographic Details
Main Authors: Yuanqing Lu, Naweed S Mohammad, Jungnam Lee, Alek M Aranyos, Karina A Serban, Mark L Brantly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0310524
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