Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study
Abstract Helicobacter pylori (H. pylori) infection is linked to metabolic syndrome and insulin resistance, with the triglyceride-glucose (TyG) index serving as a reliable marker for the latter. This study investigates the association between the TyG index and H. pylori infection. The study utilized...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84536-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559703949148160 |
|---|---|
| author | Wei Liu Jie An Cheng Jiao Jun Guo Lipu Zhang Haifeng Jin Guangchao Liu Yao Zhang |
| author_facet | Wei Liu Jie An Cheng Jiao Jun Guo Lipu Zhang Haifeng Jin Guangchao Liu Yao Zhang |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Abstract Helicobacter pylori (H. pylori) infection is linked to metabolic syndrome and insulin resistance, with the triglyceride-glucose (TyG) index serving as a reliable marker for the latter. This study investigates the association between the TyG index and H. pylori infection. The study utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2000. Participants underwent serologic testing for H. pylori, and the TyG index was calculated from fasting laboratory measurements. Multivariate logistic regression and restricted cubic spline methods were used to assess the association and explore the dose–response relationship. The analysis included 2984 participants. Elevated TyG index values were associated with an increased likelihood of H. pylori infection. The risk of infection rose with higher TyG index quartiles, with the highest quartile showing the most significant increase (OR = 1.54, 95% CI: 1.15–2.07, P = 0.004). A linear relationship between the TyG index and H. pylori infection was demonstrated. The study findings indicate a significant positive association between the TyG index and H. pylori infection. This association highlights the importance of metabolic health in the context of H. pylori infection and suggests that further research is needed to explore the potential implications for health promotion strategies. |
| format | Article |
| id | doaj-art-f300c1b02ee94f9fb47fc0a7c382220b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f300c1b02ee94f9fb47fc0a7c382220b2025-01-05T12:16:44ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84536-4Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional studyWei Liu0Jie An1Cheng Jiao2Jun Guo3Lipu Zhang4Haifeng Jin5Guangchao Liu6Yao Zhang7Department of General Surgery, Bethune International Peace HospitalDepartment of Pathology, Bethune International Peace HospitalDepartment of General Surgery, Bethune International Peace HospitalDepartment of General Surgery, Bethune International Peace HospitalDepartment of General Surgery, Bethune International Peace HospitalDepartment of Gastroenterology, Bethune International Peace HospitalDepartment of General Surgery, Bethune International Peace HospitalDepartment of General Surgery, Bethune International Peace HospitalAbstract Helicobacter pylori (H. pylori) infection is linked to metabolic syndrome and insulin resistance, with the triglyceride-glucose (TyG) index serving as a reliable marker for the latter. This study investigates the association between the TyG index and H. pylori infection. The study utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2000. Participants underwent serologic testing for H. pylori, and the TyG index was calculated from fasting laboratory measurements. Multivariate logistic regression and restricted cubic spline methods were used to assess the association and explore the dose–response relationship. The analysis included 2984 participants. Elevated TyG index values were associated with an increased likelihood of H. pylori infection. The risk of infection rose with higher TyG index quartiles, with the highest quartile showing the most significant increase (OR = 1.54, 95% CI: 1.15–2.07, P = 0.004). A linear relationship between the TyG index and H. pylori infection was demonstrated. The study findings indicate a significant positive association between the TyG index and H. pylori infection. This association highlights the importance of metabolic health in the context of H. pylori infection and suggests that further research is needed to explore the potential implications for health promotion strategies.https://doi.org/10.1038/s41598-024-84536-4Helicobacter pyloriInsulin resistanceMetabolic syndromeTriglyceride-glucose indexNational Health and Nutrition Examination Survey |
| spellingShingle | Wei Liu Jie An Cheng Jiao Jun Guo Lipu Zhang Haifeng Jin Guangchao Liu Yao Zhang Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study Scientific Reports Helicobacter pylori Insulin resistance Metabolic syndrome Triglyceride-glucose index National Health and Nutrition Examination Survey |
| title | Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study |
| title_full | Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study |
| title_fullStr | Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study |
| title_full_unstemmed | Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study |
| title_short | Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999–2000 NHANES cross-sectional study |
| title_sort | association of triglyceride glucose index with helicobacter pylori infection in the 1999 2000 nhanes cross sectional study |
| topic | Helicobacter pylori Insulin resistance Metabolic syndrome Triglyceride-glucose index National Health and Nutrition Examination Survey |
| url | https://doi.org/10.1038/s41598-024-84536-4 |
| work_keys_str_mv | AT weiliu associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT jiean associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT chengjiao associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT junguo associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT lipuzhang associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT haifengjin associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT guangchaoliu associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy AT yaozhang associationoftriglycerideglucoseindexwithhelicobacterpyloriinfectioninthe19992000nhanescrosssectionalstudy |