Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches

Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches

Abstract A new series of thiazolyl-coumarin-drug conjugates were synthesized through the reaction of 3-bromoacetylcoumarin and N-substituted and N, N-di-substituted thioureas. The synthesized compounds were characterized by1H-NMR,13C-NMR and FTIR spectroscopy and thoroughly analyzed through in-vitro...

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Bibliographic Details
Main Authors: Atteeque Ahmed, Romaisa Kanwal, Pervaiz Ali Channar, Mohammad Y. Alshahrani, Aamer Saeed, Syeda Abida Ejaz, Hafiz Muhammad Attaullah, Rifhat Bibi, Chen Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Coumarins
Thiazolyl-coumarin drugs
Substituted thioureas
Online Access:https://doi.org/10.1038/s41598-025-03115-3
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