Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure
The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts—sometimes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1480772/full |
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| author | Reem Al Monla Vincent Daien Vincent Daien Frederic Michon Frederic Michon |
| author_facet | Reem Al Monla Vincent Daien Vincent Daien Frederic Michon Frederic Michon |
| author_sort | Reem Al Monla |
| collection | DOAJ |
| description | The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts—sometimes supplemented with keratoprostheses—these options are not suitable for all corneal defects. Consequently, the development of bioartificial corneal tissue has emerged as a critical research area, aiming to address the global shortage of human cornea donors. Bioengineered corneas hold considerable promise as substitutes, with the potential to replace either specific layers or the entire thickness of damaged corneas. This review first delves into the structural anatomy of the human cornea, identifying key attributes necessary for successful corneal tissue bioengineering. It then examines various corneal pathologies, current treatments, and their limitations. Finally, the review outlines the primary approaches in corneal tissue engineering, exploring cell-free, cell-based, and scaffold-based options as three emerging strategies to address corneal failure. |
| format | Article |
| id | doaj-art-f2ae443e4cad4a11bbcc7b679422122e |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-f2ae443e4cad4a11bbcc7b679422122e2024-11-13T04:46:05ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-11-011210.3389/fbioe.2024.14807721480772Advanced bioengineering strategies broaden the therapeutic landscape for corneal failureReem Al Monla0Vincent Daien1Vincent Daien2Frederic Michon3Frederic Michon4Institute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, FranceDepartment of Ophthalmology, Gui de Chauliac Hospital, Montpellier, FranceSydney Medical School, The Save Sight Institute, The University of Sydney, Sydney, NSW, AustraliaInstitute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, FranceDepartment of Ophthalmology, Gui de Chauliac Hospital, Montpellier, FranceThe cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts—sometimes supplemented with keratoprostheses—these options are not suitable for all corneal defects. Consequently, the development of bioartificial corneal tissue has emerged as a critical research area, aiming to address the global shortage of human cornea donors. Bioengineered corneas hold considerable promise as substitutes, with the potential to replace either specific layers or the entire thickness of damaged corneas. This review first delves into the structural anatomy of the human cornea, identifying key attributes necessary for successful corneal tissue bioengineering. It then examines various corneal pathologies, current treatments, and their limitations. Finally, the review outlines the primary approaches in corneal tissue engineering, exploring cell-free, cell-based, and scaffold-based options as three emerging strategies to address corneal failure.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1480772/fullbioartificial corneatissue engineeringcorneacorneal pathologies3D bioprintinghydrogel scaffolds |
| spellingShingle | Reem Al Monla Vincent Daien Vincent Daien Frederic Michon Frederic Michon Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure Frontiers in Bioengineering and Biotechnology bioartificial cornea tissue engineering cornea corneal pathologies 3D bioprinting hydrogel scaffolds |
| title | Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| title_full | Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| title_fullStr | Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| title_full_unstemmed | Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| title_short | Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| title_sort | advanced bioengineering strategies broaden the therapeutic landscape for corneal failure |
| topic | bioartificial cornea tissue engineering cornea corneal pathologies 3D bioprinting hydrogel scaffolds |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1480772/full |
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