Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats
Intermittent fasting (IF) plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 da...
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Sakarya University
2023-06-01
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| Series: | Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2793913 |
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| author | Hikmet Taner Teker Taha Ceylani |
| author_facet | Hikmet Taner Teker Taha Ceylani |
| author_sort | Hikmet Taner Teker |
| collection | DOAJ |
| description | Intermittent fasting (IF) plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health. |
| format | Article |
| id | doaj-art-f2853fb089e94ed397b87acb1f460b3c |
| institution | Kabale University |
| issn | 2147-835X |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi |
| spelling | doaj-art-f2853fb089e94ed397b87acb1f460b3c2024-12-23T08:15:28ZengSakarya UniversitySakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi2147-835X2023-06-0127350451110.16984/saufenbilder.120995428Aortic Regeneration is Promoted by Intermittent Fasting in Aged RatsHikmet Taner Teker0https://orcid.org/0000-0002-6621-3071Taha Ceylani1https://orcid.org/0000-0002-3041-6010ANKARA MEDİPOL ÜNİVERSİTESİMUŞ ALPARSLAN ÜNİVERSİTESİIntermittent fasting (IF) plays important role in health. The regeneration that starts at the cellular level is reflected in all tissues and organs. In this study, molecular changes in the aortic tissue of 12-month-old male Wistar rats that underwent intermittent fasting for 18 hours a day for 35 days were determined by spectrochemical analysis and machine learning algoritm. While IF did not significantly affect body weights or blood glucose levels, it led to increased food and water consumption. Spectrochemical analysis revealed significant differences in the forms of DNA, specifically an increase in the A-DNA form in aortic samples. This form of DNA plays an essential role in cellular defense systems and biological processes. There was also an increase in the Amid I band, providing information about hydration status and lipid molecule interactions. Notably, a significant decrease was observed in protein phosphorylation markers, which could impact a wide range of cellular activities. IF also led to reductions in protein carbonylation, a marker of oxidative damage, and changes in the acyl chain length of fatty acids, impacting membrane fluidity. These findings suggest that IF may offer several health benefits, including improved membrane dynamics, reduced oxidative stress, and potential cellular regeneration through autophagy. Further research is needed to confirm these observations and understand their implications for human health.https://dergipark.org.tr/tr/download/article-file/2793913intermittent fastingaortaatr-ftirwistar ratintermittent fastingaortaatr-ftirwistar ratsupport vector machine |
| spellingShingle | Hikmet Taner Teker Taha Ceylani Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi intermittent fasting aorta atr-ftir wistar rat intermittent fasting aorta atr-ftir wistar rat support vector machine |
| title | Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats |
| title_full | Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats |
| title_fullStr | Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats |
| title_full_unstemmed | Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats |
| title_short | Aortic Regeneration is Promoted by Intermittent Fasting in Aged Rats |
| title_sort | aortic regeneration is promoted by intermittent fasting in aged rats |
| topic | intermittent fasting aorta atr-ftir wistar rat intermittent fasting aorta atr-ftir wistar rat support vector machine |
| url | https://dergipark.org.tr/tr/download/article-file/2793913 |
| work_keys_str_mv | AT hikmettanerteker aorticregenerationispromotedbyintermittentfastinginagedrats AT tahaceylani aorticregenerationispromotedbyintermittentfastinginagedrats |