Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease

Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19.Methods and analysis PANORAMIC is a UK-wide, open-label, pr...

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Main Authors: Najib Rahman, Andrew Carson-Stevens, Stavros Petrou, Judith Breuer, Paul Little, Melissa Dobson, Kerenza Hood, Jienchi Dorward, May Ee Png, Richard Hobbs, Gail Hayward, Mark Lown, Nigel Hart, Ly-Mee Yu, Nick Francis, Oliver van Hecke, Julie Allen, Joseph F Standing, Emma Ogburn, Jennifer Davies, Christopher C Butler, Saye Khoo, Andrew Ustianowski, Victoria Harris, Bhautesh Jani, Jane Holmes, Heather Rutter, Oghenekome Gbinigie, Lucy Cureton, Sarah Barrett, Benjamin R Saville, Monique I Andersson, Mahendra Patel, Jonathan Nguyen-Van-Tam, Duncan Richards, Layla Lavallee, David M Lowe, Tracie-Ann Madden, Joe Marion, Jem Chalk, Elizabeth Hadley, Magdalena Benysek, Mona Koshkouei, Maria Coates, Clare Bateman, Ivy Raymundo-Wood
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/8/e069176.full
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