Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT)
Background: There is a pressing need for effective treatments for major depressive disorder (MDD).Objective To examine the feasibility of an integrated mind-body MDD treatment combining cognitive behavioral therapy (CBT) and whole-body hyperthermia (WBH).Methods In this single-arm trial, 16 adults w...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2351459 |
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| author | Ashley E. Mason Anoushka Chowdhary Wendy Hartogensis Chelsea J. Siwik Osnat Lupesko-Persky Leena S. Pandya Stefanie Roberts Claudine Anglo Patricia J. Moran J. Craig Nelson Christopher A. Lowry Rhonda P. Patrick Charles L. Raison Frederick M. Hecht |
| author_facet | Ashley E. Mason Anoushka Chowdhary Wendy Hartogensis Chelsea J. Siwik Osnat Lupesko-Persky Leena S. Pandya Stefanie Roberts Claudine Anglo Patricia J. Moran J. Craig Nelson Christopher A. Lowry Rhonda P. Patrick Charles L. Raison Frederick M. Hecht |
| author_sort | Ashley E. Mason |
| collection | DOAJ |
| description | Background: There is a pressing need for effective treatments for major depressive disorder (MDD).Objective To examine the feasibility of an integrated mind-body MDD treatment combining cognitive behavioral therapy (CBT) and whole-body hyperthermia (WBH).Methods In this single-arm trial, 16 adults with MDD initially received 8 weekly CBT sessions and 8 weekly WBH sessions. Outcomes included WBH sessions completed (primary), self-report depression assessments completed (secondary), and pre-post intervention changes in depression symptoms (secondary). We also explored changes in mood and cognitive processes and assessed changes in mood as predictors of overall treatment response.Results Thirteen participants (81.3%) completed ≥ 4 WBH sessions (primary outcome); midway through the trial, we reduced from 8 weekly to 4 bi-weekly WBH sessions to increase feasibility. The n = 12 participants who attended the final assessment visit completed 100% of administered self-report depression assessments; all enrolled participants (n = 16) completed 89% of these assessments. Among the n = 12 who attended the final assessment visit, the average pre-post-intervention BDI-II reduction was 15.8 points (95% CI: −22.0, −9.70), p = 0.0001, with 11 no longer meeting MDD criteria (secondary outcomes). Pre-post intervention improvements in negative automatic thinking, but not cognitive flexibility, achieved statistical significance. Improved mood from pre-post the initial WBH session predicted pre-post treatment BDI-II change (36.2%; rho = 0.60, p = 0.038); mood changes pre-post the first CBT session did not.Limitations Small sample size and single-arm design limit generalizability.Conclusion An integrated mind-body intervention comprising weekly CBT sessions and bi-weekly WBH sessions was feasible. Results warrant future larger controlled clinical trials.Clinivaltrials.gov Registration: NCT05708976 |
| format | Article |
| id | doaj-art-f2830c75935c42a3a3e30d712eefe56c |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-f2830c75935c42a3a3e30d712eefe56c2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2351459Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT)Ashley E. Mason0Anoushka Chowdhary1Wendy Hartogensis2Chelsea J. Siwik3Osnat Lupesko-Persky4Leena S. Pandya5Stefanie Roberts6Claudine Anglo7Patricia J. Moran8J. Craig Nelson9Christopher A. Lowry10Rhonda P. Patrick11Charles L. Raison12Frederick M. Hecht13Osher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USADepartment of Psychology, University of Arizona, Tucson, AZ, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USADepartment of Wellness and Preventive Medicine, Cleveland Clinic, Cleveland, OH, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USAWeill Institute for Neurosciences, University of California San Francisco (UCSF), San Francisco, CA, USADepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USAFoundMyFitness, LLC, San Diego, CA, USADepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USAOsher Center for Integrative Health, University of California San Francisco (UCSF), San Francisco, CA, USABackground: There is a pressing need for effective treatments for major depressive disorder (MDD).Objective To examine the feasibility of an integrated mind-body MDD treatment combining cognitive behavioral therapy (CBT) and whole-body hyperthermia (WBH).Methods In this single-arm trial, 16 adults with MDD initially received 8 weekly CBT sessions and 8 weekly WBH sessions. Outcomes included WBH sessions completed (primary), self-report depression assessments completed (secondary), and pre-post intervention changes in depression symptoms (secondary). We also explored changes in mood and cognitive processes and assessed changes in mood as predictors of overall treatment response.Results Thirteen participants (81.3%) completed ≥ 4 WBH sessions (primary outcome); midway through the trial, we reduced from 8 weekly to 4 bi-weekly WBH sessions to increase feasibility. The n = 12 participants who attended the final assessment visit completed 100% of administered self-report depression assessments; all enrolled participants (n = 16) completed 89% of these assessments. Among the n = 12 who attended the final assessment visit, the average pre-post-intervention BDI-II reduction was 15.8 points (95% CI: −22.0, −9.70), p = 0.0001, with 11 no longer meeting MDD criteria (secondary outcomes). Pre-post intervention improvements in negative automatic thinking, but not cognitive flexibility, achieved statistical significance. Improved mood from pre-post the initial WBH session predicted pre-post treatment BDI-II change (36.2%; rho = 0.60, p = 0.038); mood changes pre-post the first CBT session did not.Limitations Small sample size and single-arm design limit generalizability.Conclusion An integrated mind-body intervention comprising weekly CBT sessions and bi-weekly WBH sessions was feasible. Results warrant future larger controlled clinical trials.Clinivaltrials.gov Registration: NCT05708976https://www.tandfonline.com/doi/10.1080/02656736.2024.2351459Whole-body hyperthermiabody temperaturefeasibilityacceptabilitydepression |
| spellingShingle | Ashley E. Mason Anoushka Chowdhary Wendy Hartogensis Chelsea J. Siwik Osnat Lupesko-Persky Leena S. Pandya Stefanie Roberts Claudine Anglo Patricia J. Moran J. Craig Nelson Christopher A. Lowry Rhonda P. Patrick Charles L. Raison Frederick M. Hecht Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) International Journal of Hyperthermia Whole-body hyperthermia body temperature feasibility acceptability depression |
| title | Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) |
| title_full | Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) |
| title_fullStr | Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) |
| title_full_unstemmed | Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) |
| title_short | Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) |
| title_sort | feasibility and acceptability of an integrated mind body intervention for depression whole body hyperthermia wbh and cognitive behavioral therapy cbt |
| topic | Whole-body hyperthermia body temperature feasibility acceptability depression |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2351459 |
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