Decoding MUC1 and AR axis in a radiation-induced neuroendocrine prostate cancer cell-subpopulation unveils novel therapeutic targets
Abstract Despite the initial efficacy of radiotherapy (RT) in treating prostate adenocarcinoma (PCa), disease progression can lead to the emergence of neuroendocrine prostate cancer (NEPC) - a highly aggressive malignancy for which standard therapies are mostly ineffective. Although oncogenic MUC1-C...
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| Main Authors: | Catarina Macedo-Silva, Ângela Albuquerque-Castro, Iris Carriço, Joana Lencart, Isa Carneiro, Lucia Altucci, João Lobo, Vera Miranda-Gonçalves, Rui Henrique, Margareta P. Correia, Carmen Jerónimo |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02597-4 |
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