Characterization and functional evaluation of goat PDX1 regulatory modules through comparative analysis of conserved interspecies homologs

Characterization and functional evaluation of goat PDX1 regulatory modules through comparative analysis of conserved interspecies homologs

Abstract PDX1 is a crucial transcription factor in pancreas development and mature β-cell function. However, the regulation of PDX1 expression in larger animals mirroring human pancreas morphogenesis and endocrine maturation remains poorly understood. Therefore, we conducted a comparative analysis t...

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Main Authors: Naeimeh Rezaei, Kianoush Dormiani, Abbas Kiani-Esfahani, Somayeh Mirdamadian, Mohsen Rahmani, Farnoosh Jafarpour, Mohammad Hossein Nasr-Esfahani
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pancreas development
Islet beta cell (β-cell)
PDX1
Tissue‐specific transcription factor
Diabetes
Cis-Regulatory elements
Online Access:https://doi.org/10.1038/s41598-024-77614-0
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https://doi.org/10.1038/s41598-024-77614-0

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