Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer
Abstract Background Stereotactic body radiation therapy (SBRT) has been widely used for pancreatic cancer. However, there is still a lack of studies comparing the latest SBRT techniques in terms of clinical efficacy and safety. Objectives: This study aims to evaluate three latest SBRT delivery platf...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02080-3 |
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| author | Yongchun Song Xiuli Chen Xuyao Yu Yang Dong Jia Tian Xin Wang Yuwen Wang Bo Jiang |
| author_facet | Yongchun Song Xiuli Chen Xuyao Yu Yang Dong Jia Tian Xin Wang Yuwen Wang Bo Jiang |
| author_sort | Yongchun Song |
| collection | DOAJ |
| description | Abstract Background Stereotactic body radiation therapy (SBRT) has been widely used for pancreatic cancer. However, there is still a lack of studies comparing the latest SBRT techniques in terms of clinical efficacy and safety. Objectives: This study aims to evaluate three latest SBRT delivery platforms: CyberKnife (CK), Tomography Radixact (TOMO), and Halcyon volume rotation intensity modulation therapy (VMAT) for the treatment of pancreatic cancer. Methods Sixteen patients with pancreatic cancer treated with CK were retrospectively analyzed. SBRT plans were designed using Precision and Eclipse software. CK plans were optimized in two forms: fixed collimator (CK-Fixed) and multi-leaf grating collimator (CK-MLC). TOMO plans were designed with 2.5 cm Fixed Jaw, pitch 0.123–0.43 and 4.0 modulation factors in precision system. In Eclipse 15.6 system, photon optimizer (OP) algorithm was used to design the coplanar two-arc Halcyon VMAT. The median radiation dose was 40 Gy (35–45 Gy) in 5 fractions. The effectiveness of clinical treatment was evaluated by comparing the homogeneity index (HI), conformity index (CI), coverage of the planning target volume (PTV) and dose distribution parameters of organs at risk (OAR). Results All plans met the limits of clinical target dose and OAR. CK-MLC plans had the lowest maximum dose of 2 cm normal tissue from PTV margin (D2cm), indicating a low risk of peripheral radiation damage. Additionally, the CK-MLC plans had the lowest dose parameters and provided the best protection for the kidney, spinal cord, small intestine, and duodenum, with a paired t-test p < 0.05, indicating a statistical difference. Conclusion High conformity and adjustability of CK-MLC allowed for precise complex target localization and conformal dose distribution, benefiting tumor treatment while maximally reducing damage to OAR. This study provides valuable dosimetric evidence for SBRT technique selection for pancreatic cancer. |
| format | Article |
| id | doaj-art-f22511c897064631926d4e51b2d9be4c |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-f22511c897064631926d4e51b2d9be4c2024-11-10T12:14:05ZengBMCEuropean Journal of Medical Research2047-783X2024-11-012911710.1186/s40001-024-02080-3Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancerYongchun Song0Xiuli Chen1Xuyao Yu2Yang Dong3Jia Tian4Xin Wang5Yuwen Wang6Bo Jiang7Department of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Radiotherapy, Tianjin HospitalDepartment of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Radiation Oncology, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Radiotherapy, Tianjin Cancer Hospital Airport HospitalDepartment of Radiotherapy, Tianjin Cancer Hospital Airport HospitalAbstract Background Stereotactic body radiation therapy (SBRT) has been widely used for pancreatic cancer. However, there is still a lack of studies comparing the latest SBRT techniques in terms of clinical efficacy and safety. Objectives: This study aims to evaluate three latest SBRT delivery platforms: CyberKnife (CK), Tomography Radixact (TOMO), and Halcyon volume rotation intensity modulation therapy (VMAT) for the treatment of pancreatic cancer. Methods Sixteen patients with pancreatic cancer treated with CK were retrospectively analyzed. SBRT plans were designed using Precision and Eclipse software. CK plans were optimized in two forms: fixed collimator (CK-Fixed) and multi-leaf grating collimator (CK-MLC). TOMO plans were designed with 2.5 cm Fixed Jaw, pitch 0.123–0.43 and 4.0 modulation factors in precision system. In Eclipse 15.6 system, photon optimizer (OP) algorithm was used to design the coplanar two-arc Halcyon VMAT. The median radiation dose was 40 Gy (35–45 Gy) in 5 fractions. The effectiveness of clinical treatment was evaluated by comparing the homogeneity index (HI), conformity index (CI), coverage of the planning target volume (PTV) and dose distribution parameters of organs at risk (OAR). Results All plans met the limits of clinical target dose and OAR. CK-MLC plans had the lowest maximum dose of 2 cm normal tissue from PTV margin (D2cm), indicating a low risk of peripheral radiation damage. Additionally, the CK-MLC plans had the lowest dose parameters and provided the best protection for the kidney, spinal cord, small intestine, and duodenum, with a paired t-test p < 0.05, indicating a statistical difference. Conclusion High conformity and adjustability of CK-MLC allowed for precise complex target localization and conformal dose distribution, benefiting tumor treatment while maximally reducing damage to OAR. This study provides valuable dosimetric evidence for SBRT technique selection for pancreatic cancer.https://doi.org/10.1186/s40001-024-02080-3Pancreatic cancerSBRTCyberknifeTOMOHalcyon VMAT |
| spellingShingle | Yongchun Song Xiuli Chen Xuyao Yu Yang Dong Jia Tian Xin Wang Yuwen Wang Bo Jiang Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer European Journal of Medical Research Pancreatic cancer SBRT Cyberknife TOMO Halcyon VMAT |
| title | Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer |
| title_full | Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer |
| title_fullStr | Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer |
| title_full_unstemmed | Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer |
| title_short | Dosimetric comparison of multiple SBRT delivery platforms for pancreatic cancer |
| title_sort | dosimetric comparison of multiple sbrt delivery platforms for pancreatic cancer |
| topic | Pancreatic cancer SBRT Cyberknife TOMO Halcyon VMAT |
| url | https://doi.org/10.1186/s40001-024-02080-3 |
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