CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway

CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway

BackgroundChronic allograft dysfunction (CAD) stands as a critical factor that limits the long-term viability of transplanted kidneys. Ferroptosis is an iron-dependent form of programmed cell death increasingly linked to chronic fibrosis. However, the mechanism by which ferroptosis contributes to th...

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Bibliographic Details
Main Authors: Qianguang Han, Bin Ni, Wei Bao, Junqi Zhang, Ming Zheng, Jinxu Miu, Zijie Wang, Jingwen Yuan, Jun Tao, Zhijian Han, Min Gu, Xiaobing Ju, Ruoyun Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
chronic renal graft dysfunction (CAD)
epithelial-mesenchymal transition (EMT)
ferroptosis
Caveolin-1(CAV1)
Interleukin-6 (IL-6)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523855/full
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