Tailored intervention improves statin adherence and reduces LDL-cholesterol levels
Background: Inadequate compliance with statin therapy considerably affects the achievement of low-density lipoprotein cholesterol (LDL-C) objectives. Tailored interventions aim to address individual patient barriers to improve medication adherence. Objective: The objective of this study wa...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-08-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/158156/download/pdf/ |
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| author | Wenny Putri Nilamsari Novika Selvia Putri Mochamad Yusuf Alsagaff Halim Priyahau Jaya Budi Suprapti Neni Tri Astuti Hikmah Urwatil Wusqo |
| author_facet | Wenny Putri Nilamsari Novika Selvia Putri Mochamad Yusuf Alsagaff Halim Priyahau Jaya Budi Suprapti Neni Tri Astuti Hikmah Urwatil Wusqo |
| author_sort | Wenny Putri Nilamsari |
| collection | DOAJ |
| description | Background: Inadequate compliance with statin therapy considerably affects the achievement of low-density lipoprotein cholesterol (LDL-C) objectives. Tailored interventions aim to address individual patient barriers to improve medication adherence. Objective: The objective of this study was to assess the efficacy of a tailored intervention in improving statin adherence and reducing LDL-C levels in patients with atherosclerotic cardiovascular disease (ASCVD). Methods: A prospective one-group study utilizing a pre-test and post-test design was conducted, involving 70 patients. The inclusion criteria were: 1) patients with baseline LDL-C values recorded prior to the intervention; 2) patients who had undergone 40 mg atorvastatin therapy for a minimum of three months without reaching LDL-C targets; and 3) non-adherent patients. Adherence was assessed using the Short Form of the Adherence to Refills and Medications Scale (ARMS-SF) questionnaire. Results: After the intervention, adherence improved significantly from 0% to 90% (p < 0.001), accompanied by a significant reduction in mean LDL-C levels from 100.19 mg/dL to 87.29 mg/dL (p < 0.001). Conclusion: Tailored intervention significantly improved adherence and reduced LDL-C levels. This method can be recommended as an effective strategy to improve medication adherence prior to therapy intensification or polymorphism testing in patients on high-intensity statin therapy. |
| format | Article |
| id | doaj-art-f1e760b863634b50b10c2bbf92479f4b |
| institution | Kabale University |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-f1e760b863634b50b10c2bbf92479f4b2025-08-20T03:36:14ZengPensoft PublishersPharmacia2603-557X2025-08-01721710.3897/pharmacia.72.e158156158156Tailored intervention improves statin adherence and reduces LDL-cholesterol levelsWenny Putri Nilamsari0Novika Selvia Putri1Mochamad Yusuf Alsagaff2Halim Priyahau Jaya3Budi Suprapti4Neni Tri Astuti5Hikmah Urwatil Wusqo6Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaDepartment of Clinical Pharmacy, Dr. Soetomo Teaching HospitalUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaBackground: Inadequate compliance with statin therapy considerably affects the achievement of low-density lipoprotein cholesterol (LDL-C) objectives. Tailored interventions aim to address individual patient barriers to improve medication adherence. Objective: The objective of this study was to assess the efficacy of a tailored intervention in improving statin adherence and reducing LDL-C levels in patients with atherosclerotic cardiovascular disease (ASCVD). Methods: A prospective one-group study utilizing a pre-test and post-test design was conducted, involving 70 patients. The inclusion criteria were: 1) patients with baseline LDL-C values recorded prior to the intervention; 2) patients who had undergone 40 mg atorvastatin therapy for a minimum of three months without reaching LDL-C targets; and 3) non-adherent patients. Adherence was assessed using the Short Form of the Adherence to Refills and Medications Scale (ARMS-SF) questionnaire. Results: After the intervention, adherence improved significantly from 0% to 90% (p < 0.001), accompanied by a significant reduction in mean LDL-C levels from 100.19 mg/dL to 87.29 mg/dL (p < 0.001). Conclusion: Tailored intervention significantly improved adherence and reduced LDL-C levels. This method can be recommended as an effective strategy to improve medication adherence prior to therapy intensification or polymorphism testing in patients on high-intensity statin therapy.https://pharmacia.pensoft.net/article/158156/download/pdf/ |
| spellingShingle | Wenny Putri Nilamsari Novika Selvia Putri Mochamad Yusuf Alsagaff Halim Priyahau Jaya Budi Suprapti Neni Tri Astuti Hikmah Urwatil Wusqo Tailored intervention improves statin adherence and reduces LDL-cholesterol levels Pharmacia |
| title | Tailored intervention improves statin adherence and reduces LDL-cholesterol levels |
| title_full | Tailored intervention improves statin adherence and reduces LDL-cholesterol levels |
| title_fullStr | Tailored intervention improves statin adherence and reduces LDL-cholesterol levels |
| title_full_unstemmed | Tailored intervention improves statin adherence and reduces LDL-cholesterol levels |
| title_short | Tailored intervention improves statin adherence and reduces LDL-cholesterol levels |
| title_sort | tailored intervention improves statin adherence and reduces ldl cholesterol levels |
| url | https://pharmacia.pensoft.net/article/158156/download/pdf/ |
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