Diagnostic value of the correlation between urinary MDM2 and podocyte mitotic catastrophe in diabetic kidney disease

Diagnostic value of the correlation between urinary MDM2 and podocyte mitotic catastrophe in diabetic kidney disease

Abstract Background Podocytic injury and shedding are critical events in the progression and prognosis of diabetic nephropathy (DN). The purpose of our study was to observe heterokaryotic podocytes caused by mitotic catastrophe and the levels of murine double minute gene 2 (MDM2) and synaptopodin (S...

Full description

Saved in:

Bibliographic Details
Main Authors:	Li Xu, Xiuli Guo, Wen Gan, Linhong Yao, Jianing Wang, Qi Li, Qiuling Fan
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Diabetology & Metabolic Syndrome
Subjects:	Diabetic kidney disease Podocyte Mitosis catastrophe MDM2 Synaptopodin
Online Access:	https://doi.org/10.1186/s13098-025-01856-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer
by: Sonia Valentini, et al.
Published: (2025-08-01)

Podocyte epithelial-mesenchymal transdifferentiation and glomerular disease
by: CHEN Hai-yun, et al.
Published: (2020-01-01)

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast
by: Yueyue Jiang, et al.
Published: (2025-08-01)

Expressions of nephrin and desmin in podocyte of HUA rats and intervention of febuxostat
by: Wu Wei-bin, et al.
Published: (2021-01-01)

Effects of lycopene on high glucose-induced autophagy and apoptosis of podocytes
by: LI Ni, et al.
Published: (2018-01-01)

The Role of Nuclear Phosphoinositides in the p53-MDM2 Nexus
by: Jeong Hyo Lee, et al.
Published: (2025-07-01)

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B‐cell lymphoma
by: Katharina Engel, et al.
Published: (2016-06-01)

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment
by: Xiaoxiao Huang, et al.
Published: (2023-12-01)

Effects of dapagliflozin on podocyte damage and oxidative stress in patients with diabetic nephropathy
by: Yajing Shi, et al.
Published: (2025-08-01)

Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis
by: Rocío Valle-Bautista, et al.
Published: (2025-05-01)

Association between ТР53, MDM2 and NQO1 gene polymorphisms and viral load among women with human papillomavirus
by: A.H. AlBosale, et al.
Published: (2022-03-01)

Autophagy in patients with lupus nephritis and its effect on podocyte related protein expression
by: LI Zhang-hong, et al.
Published: (2020-01-01)

Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells
by: Sean F. Cooke, et al.
Published: (2025-09-01)

THE ROLE OF PUBLIC PRIVATE PARTNERSHIP IN DEVELOPING CATASTROPHE INSURANCE MARKET
by: Darko Blazhevski
Published: (2019-11-01)

Research adavances of podocyte damage mechanism and traditional Chinese medicine intervention in diabetic kidney disease
by: Wen Xiao-chen, et al.
Published: (2021-01-01)

IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement
by: Guanyu Li, et al.
Published: (2025-06-01)

Research on podocyte injury mechanisms in diabetic nephropathy: a bibliometric and knowledge-map analysis from 2000 to 2024
by: Yanmei Lin, et al.
Published: (2025-08-01)

Inhibition of angiotensin Ⅱ type 1 receptor on Renal Fibrosis and Podocyte Damage in Angiotensin Ⅱ-induced Hypertensive Nephropathy
by: Zhang He-ping, et al.
Published: (2022-04-01)

CHROMOSOMAL VARIATION IN Vanilla planifolia Jacks. (ORCHIDACEAE)
by: Lourdes Iglesias Andreu, et al.
Published: (2025-07-01)

Depression, Anxiety, and Pain Catastrophizing in Migraine Patients
by: Fatih İnci, et al.
Published: (2023-06-01)

Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure
by: Christina Ising, et al.
Published: (2015-02-01)

Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors
by: Xinjiang Wang, et al.
Published: (2025-06-01)

PARAMETRIC INSURANCE COVER FOR NATURAL CATASTROPHE RISKS
by: Serghei Margulescu, et al.
Published: (2013-11-01)

Research on a New Type of Ring-core Fiber and Mode Selective Coupler
by: XU Qingxiang, et al.
Published: (2025-04-01)

The economic toll of cancer: catastrophic expenditure and impoverishment among lower-income households in Malaysia
by: Farhana Aminuddin, et al.
Published: (2025-07-01)

Mitigating Catastrophic Forgetting in Pest Detection Through Adaptive Response Distillation
by: Hongjun Zhang, et al.
Published: (2025-05-01)

The Psychological Well-Being, Catastrophizing, and Quality of Life of Among Women Diagnosed with Endometriosis
by: Keren Grinberg, et al.
Published: (2024-04-01)

Notch signaling in diabetic kidney disease: recent progress
by: Zhi-Hui Wang, et al.
Published: (2025-07-01)

Combination therapy with DHA and BMSCs suppressed podocyte injury and attenuated renal fibrosis by modulating the TGF-β1/Smad pathway in MN mice
by: Yongzhang Li, et al.
Published: (2023-12-01)

Acute interstitial tubular nephritis with foot process fusion caused by acetaminophen:a case report and literature review
by: Dong Ze-Xuan, et al.
Published: (2021-01-01)

Machine learning based classification of catastrophic health expenditures: a cross-sectional study of Korean low-income households
by: Seok Min Ji, et al.
Published: (2025-08-01)

Association of knee joint performance and gait patterns with pain catastrophizing in patients with severe knee osteoarthritis: a cross-sectional study
by: Hideaki Matsuo, et al.
Published: (2025-07-01)

Indonesian Economy Under the Shadow of Catastrophic Natural Disasters: Empirical Evidences from Additive Mixed Model With P-Spline Smooth Function
by: Taly Purwa, et al.
Published: (2024-09-01)

Blue Sky Catastrophe in Systems with Non-classical Relaxation Oscillations
by: S. D. Glyzin, et al.
Published: (2015-02-01)

Catastrophic antiphospholipid COVID-19 syndrome
by: Yu. S. Polushin, et al.
Published: (2021-03-01)

Out-of-pocket payment and catastrophic health expenditure of tuberculosis patients in accessing care at public-private mix clinics in Myanmar, 2022
by: Myat Noe Thiri Khaing, et al.
Published: (2024-11-01)

Catastrophic Health Expenditure and Its Determinants in Patients With Ischemic Heart Disease and Their Households: A Cross‐Sectional Study From Iran in 2024
by: Mohammad Ali Laali Dehaghi, et al.
Published: (2025-07-01)

Catastrophic-risk-aware reinforcement learning with extreme-value-theory-based policy gradients☆
by: Parisa Davar, et al.
Published: (2025-12-01)

Clinical and laboratory characteristics of the patterns of chronic kidney disease in patients with type 2 diabetes
by: Vadim V. Klimontov, et al.
Published: (2019-12-01)

Some mysterious catastrophes of the last hundred years from the point of view of non-local physics
by: B. V. Alexeev
Published: (2014-04-01)