Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review
Skin aging is a multifaceted and gradual process influenced by both internal and external factors, including environmental stressors. These two mechanisms contribute to oxidative stress, triggered by ROS, which accelerates the aging of the skin. UV exposure increases the production of ROS in cells,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Aspects of Molecular Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949688825000012 |
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| author | Narmin Hama amin Hussen Sakar Karem Abdulla Naza Mohammed Ali Van Abdulqader Ahmed Aso Hameed Hasan Eman Erfan Qadir |
| author_facet | Narmin Hama amin Hussen Sakar Karem Abdulla Naza Mohammed Ali Van Abdulqader Ahmed Aso Hameed Hasan Eman Erfan Qadir |
| author_sort | Narmin Hama amin Hussen |
| collection | DOAJ |
| description | Skin aging is a multifaceted and gradual process influenced by both internal and external factors, including environmental stressors. These two mechanisms contribute to oxidative stress, triggered by ROS, which accelerates the aging of the skin. UV exposure increases the production of ROS in cells, which collectively contribute to the various skin changes linked to aging. However, the skin has a sophisticated antioxidant defense system that shields it from oxidative damage caused by both internal and external factors. The use of topical antioxidants have been shown to shield the skin from harmful free radicals generated intrinsically by regular cellular metabolism or as a result of UV light exposure. This review focuses on the assessment of the injury environmental factors cause to the skin, molecular mechanism of ROS in the skin aging, and the use of antioxidants to prevent that damaging and producing a protection against UV radiation from environmental factors. The systematic search was done for eligible articles which including in vivo and in vitro studies from studies between (1997 until 2024). |
| format | Article |
| id | doaj-art-f1dacd4e5bca43d7911eed9aa32dabd6 |
| institution | Kabale University |
| issn | 2949-6888 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aspects of Molecular Medicine |
| spelling | doaj-art-f1dacd4e5bca43d7911eed9aa32dabd62025-01-09T06:17:07ZengElsevierAspects of Molecular Medicine2949-68882025-06-015100063Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive reviewNarmin Hama amin Hussen0Sakar Karem Abdulla1Naza Mohammed Ali2Van Abdulqader Ahmed3Aso Hameed Hasan4Eman Erfan Qadir5Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, University of Sulaimani, Sulaymaniyah, 46001, Iraq; Corresponding author.Department of Basic Sciences, College of Pharmacy, University of Sulaimani, Sulaymaniyah, 46001, IraqDepartment of Pharmacology & Toxicology, College of Pharmacy, University of Sulaimani, Sulaymaniyah, 46001, IraqDepartment of Basic Sciences, College of Pharmacy, University of Sulaimani, Sulaymaniyah, 46001, IraqDepartment of Chemistry, College of Science, University of Garmian, Kalar, 46021, Sulaymaniyah, Iraq; Corresponding author.Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, University of Sulaimani, Sulaymaniyah, 46001, IraqSkin aging is a multifaceted and gradual process influenced by both internal and external factors, including environmental stressors. These two mechanisms contribute to oxidative stress, triggered by ROS, which accelerates the aging of the skin. UV exposure increases the production of ROS in cells, which collectively contribute to the various skin changes linked to aging. However, the skin has a sophisticated antioxidant defense system that shields it from oxidative damage caused by both internal and external factors. The use of topical antioxidants have been shown to shield the skin from harmful free radicals generated intrinsically by regular cellular metabolism or as a result of UV light exposure. This review focuses on the assessment of the injury environmental factors cause to the skin, molecular mechanism of ROS in the skin aging, and the use of antioxidants to prevent that damaging and producing a protection against UV radiation from environmental factors. The systematic search was done for eligible articles which including in vivo and in vitro studies from studies between (1997 until 2024).http://www.sciencedirect.com/science/article/pii/S2949688825000012Skin agingOxidative stressAntioxidantUV radiationSkin protectionReactive oxygen species |
| spellingShingle | Narmin Hama amin Hussen Sakar Karem Abdulla Naza Mohammed Ali Van Abdulqader Ahmed Aso Hameed Hasan Eman Erfan Qadir Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review Aspects of Molecular Medicine Skin aging Oxidative stress Antioxidant UV radiation Skin protection Reactive oxygen species |
| title | Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review |
| title_full | Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review |
| title_fullStr | Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review |
| title_full_unstemmed | Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review |
| title_short | Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review |
| title_sort | role of antioxidants in skin aging and the molecular mechanism of ros a comprehensive review |
| topic | Skin aging Oxidative stress Antioxidant UV radiation Skin protection Reactive oxygen species |
| url | http://www.sciencedirect.com/science/article/pii/S2949688825000012 |
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