IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation

IMRC-exo alleviates limb injury by inhibiting ferroptosis in a rabbit model of deinagkistrodon acutus snakebite envenomation

Abstract Deinagkistrodon acutus is one of the unique venomous snakes native to Southeast Asia. Limb injury caused by this species is the main cause of disability in snake bite patients, while the relevant pathogenesis mechanism and intervention strategies need to be further explored. In recent years...

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Bibliographic Details
Main Authors: Linjie Lai, Wang Du, Haohao Wu, Wanjuan Liu, Ke lv, Peixin Shangguan, Lutao Xie, Jiefeng Xu, Pin Lan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Deinagkistrodon acutus
Snake venom
Limb muscle injury
Immunity-and-matrix regulatory cells-derived exosome (IMRC-Exo)
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-10746-z
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https://doi.org/10.1038/s41598-025-10746-z

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