A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina
ABSTRACT Objective: The hemostatic and matrix metalloproteinase (MMP) systems are known to be altered in patients with breast cancer. This cross-sectional study aimed to explore the fibrinolysis components values and MMP-9 levels in a specific population of patients with early breast cancer and met...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2025-04-01
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| author | Mariano Nicolás Áleman María Constanza Luciardi Rosa Silvina Guber Analía Graciela Soria |
| author_facet | Mariano Nicolás Áleman María Constanza Luciardi Rosa Silvina Guber Analía Graciela Soria |
| author_sort | Mariano Nicolás Áleman |
| collection | DOAJ |
| description | ABSTRACT Objective: The hemostatic and matrix metalloproteinase (MMP) systems are known to be altered in patients with breast cancer. This cross-sectional study aimed to explore the fibrinolysis components values and MMP-9 levels in a specific population of patients with early breast cancer and metastatic breast cancer in Tucumán, Argentina. Methods: This cross-sectional study included 63 patients without pathology or with benign breast pathology (GA Group), 48 patients with newly diagnosed primary breast cancer (GB Group), and 65 patients with metastatic breast cancer (GC Group). Levels of standard coagulation tests, tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), D-dimer (DD), and matrix metalloproteinases-9 (MMP-9) were measured in all groups. Results: PAI-1 and MMP-9 levels were higher in patient with early breast cancer than those with benign disease. However, the GC Group showed significantly higher PAI-1, DD, and MMP-9 levels than the GA Group. Furthermore, the t-PA concentrations in the GC Group were lower than those in the Control Group. Conclusion: Our findings suggest that higher levels of PAI-1 and MMP-9 in patients with early-stage breast cancer may be associated with a subgroup of patients with more aggressive disease progression. In addition, significant alterations in t-PA, PAI-1, DD, and MMP-9 concentrations were observed in advanced stages of the disease. However, basic laboratory tests, such as global coagulation tests, do not effectively differentiate stages in breast cancer. Therefore, further study is needed to explore these findings in greater detail. |
| format | Article |
| id | doaj-art-f1b5a477bcb44be097b80f1ee4da9327 |
| institution | Kabale University |
| issn | 2317-6385 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj-art-f1b5a477bcb44be097b80f1ee4da93272025-08-20T03:52:32ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852025-04-012310.31744/einstein_journal/2025ao1237A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, ArgentinaMariano Nicolás Álemanhttps://orcid.org/0000-0003-3073-7540María Constanza Luciardihttps://orcid.org/0000-0001-5729-1089Rosa Silvina Guberhttps://orcid.org/0000-0001-6526-6043Analía Graciela Soriahttps://orcid.org/0000-0003-2702-9594ABSTRACT Objective: The hemostatic and matrix metalloproteinase (MMP) systems are known to be altered in patients with breast cancer. This cross-sectional study aimed to explore the fibrinolysis components values and MMP-9 levels in a specific population of patients with early breast cancer and metastatic breast cancer in Tucumán, Argentina. Methods: This cross-sectional study included 63 patients without pathology or with benign breast pathology (GA Group), 48 patients with newly diagnosed primary breast cancer (GB Group), and 65 patients with metastatic breast cancer (GC Group). Levels of standard coagulation tests, tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), D-dimer (DD), and matrix metalloproteinases-9 (MMP-9) were measured in all groups. Results: PAI-1 and MMP-9 levels were higher in patient with early breast cancer than those with benign disease. However, the GC Group showed significantly higher PAI-1, DD, and MMP-9 levels than the GA Group. Furthermore, the t-PA concentrations in the GC Group were lower than those in the Control Group. Conclusion: Our findings suggest that higher levels of PAI-1 and MMP-9 in patients with early-stage breast cancer may be associated with a subgroup of patients with more aggressive disease progression. In addition, significant alterations in t-PA, PAI-1, DD, and MMP-9 concentrations were observed in advanced stages of the disease. However, basic laboratory tests, such as global coagulation tests, do not effectively differentiate stages in breast cancer. Therefore, further study is needed to explore these findings in greater detail.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082025000100218&lng=en&tlng=enBreast neoplasmsBreast diseaseMetastasis neoplasmsFibrinolysisMatrix metalloproteinaseStandard coagulation testsPlasminogen activator inhibitor 1 |
| spellingShingle | Mariano Nicolás Áleman María Constanza Luciardi Rosa Silvina Guber Analía Graciela Soria A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina Einstein (São Paulo) Breast neoplasms Breast disease Metastasis neoplasms Fibrinolysis Matrix metalloproteinase Standard coagulation tests Plasminogen activator inhibitor 1 |
| title | A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina |
| title_full | A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina |
| title_fullStr | A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina |
| title_full_unstemmed | A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina |
| title_short | A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina |
| title_sort | cross sectional study on the expression of fibrinolytic system components and metalloproteinase 9 in women with early stage and metastases breast cancer in tucuman argentina |
| topic | Breast neoplasms Breast disease Metastasis neoplasms Fibrinolysis Matrix metalloproteinase Standard coagulation tests Plasminogen activator inhibitor 1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082025000100218&lng=en&tlng=en |
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