Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research

Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research

Objective: Infiltration of adipocytes into the pancreatic parenchyma has been linked to impaired insulin secretion in individuals with increased genetic risk of T2D and prediabetic conditions. However, the study of this ectopic fat depot has been limited by the lack of suitable in vitro models. Meth...

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Main Authors: E. Lorza-Gil, O.D. Strauss, E. Ziegler, K. Kansy, M.-T. Katschke, G. Rahimi, D. Neuscheler, L. Sandforth, A. Sandforth, G. Sancar, B. Kaufmann, D. Hartmann, S. Singer, A.L. Mihaljevic, R. Jumpertz-von Schwartzenberg, J. Sbierski-Kind, T.D. Müller, A.L. Birkenfeld, F. Gerst
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
Pancreatic adipose tissue
Organoids
Adipogenesis
Incretins
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001984
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