Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus
Human respiratory syncytial virus (hRSV) remains a leading cause of morbidity and mortality in infants, young children, and older adults. hRSV infection's limited treatment and vaccine options significantly increase bronchiolitis' morbidity rates. The severity and outcome of viral infectio...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Virus Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S016817022400176X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846116214485549056 |
|---|---|
| author | Abayeneh Girma |
| author_facet | Abayeneh Girma |
| author_sort | Abayeneh Girma |
| collection | DOAJ |
| description | Human respiratory syncytial virus (hRSV) remains a leading cause of morbidity and mortality in infants, young children, and older adults. hRSV infection's limited treatment and vaccine options significantly increase bronchiolitis' morbidity rates. The severity and outcome of viral infection hinge on the innate immune response. Developing vaccines and identifying therapeutic interventions suitable for young children, older adults, and pregnant women relies on comprehending the molecular mechanisms of viral PAMP recognition, genetic factors of the inflammatory response, and antiviral defense. This review covers fundamental elements of hRSV biology, diagnosis, pathogenesis, and the immune response, highlighting prospective options for vaccine development. |
| format | Article |
| id | doaj-art-f1a5b3d4b3494335997e0b1d7543eeef |
| institution | Kabale University |
| issn | 1872-7492 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Virus Research |
| spelling | doaj-art-f1a5b3d4b3494335997e0b1d7543eeef2024-12-19T10:52:17ZengElsevierVirus Research1872-74922024-12-01350199483Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virusAbayeneh Girma0Department of Biology, College of Natural and Computational Sciences, Mekdela Amba University, P.O. Box 32, Tulu Awuliya, EthiopiaHuman respiratory syncytial virus (hRSV) remains a leading cause of morbidity and mortality in infants, young children, and older adults. hRSV infection's limited treatment and vaccine options significantly increase bronchiolitis' morbidity rates. The severity and outcome of viral infection hinge on the innate immune response. Developing vaccines and identifying therapeutic interventions suitable for young children, older adults, and pregnant women relies on comprehending the molecular mechanisms of viral PAMP recognition, genetic factors of the inflammatory response, and antiviral defense. This review covers fundamental elements of hRSV biology, diagnosis, pathogenesis, and the immune response, highlighting prospective options for vaccine development.http://www.sciencedirect.com/science/article/pii/S016817022400176XhRSVViral diagnosisPathogenesisImmune responseCurrent vaccines against hRSV |
| spellingShingle | Abayeneh Girma Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus Virus Research hRSV Viral diagnosis Pathogenesis Immune response Current vaccines against hRSV |
| title | Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus |
| title_full | Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus |
| title_fullStr | Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus |
| title_full_unstemmed | Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus |
| title_short | Biology of human respiratory syncytial virus: Current perspectives in immune response and mechanisms against the virus |
| title_sort | biology of human respiratory syncytial virus current perspectives in immune response and mechanisms against the virus |
| topic | hRSV Viral diagnosis Pathogenesis Immune response Current vaccines against hRSV |
| url | http://www.sciencedirect.com/science/article/pii/S016817022400176X |
| work_keys_str_mv | AT abayenehgirma biologyofhumanrespiratorysyncytialviruscurrentperspectivesinimmuneresponseandmechanismsagainstthevirus |